Journal article
Sticking Detection by Repeated Compactions on a Single Tablet
AAPS PharmSciTech, v 24(8), pp 237-237
21 Nov 2023
PMID: 37989970
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
"Sticking" during tablet manufacture is the term used to describe the accumulation of adhered tablet material on the punch over the course of several compaction cycles. The occurrence of sticking can affect tablet weight, image, and structural integrity and halt manufacturing operations. The earlier the risk of sticking is detected during R&D, the more options are available for mitigation and the less potential there is for significant delays and costs. The detection osf sticking, however, during the early stages of drug development is challenging due to the limitations of available material quantity. In this work, single tablet multi-compaction (STMC) and a highly sensitive laser reflection sensor are used to detect the propensity of sticking with ibuprofen powder blends. STMC can differentiate the various formulations and replicates the trends of sticking at different punch speeds. The results demonstrate the potential for STMC to be used as an extremely material sparing (requiring very few tablets) methodology for the assessment of sticking during early-stage development.
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Details
- Title
- Sticking Detection by Repeated Compactions on a Single Tablet
- Creators
- James Thomas - GlaxoSmithKline, Drug Subst Dev Mat Sci, 1250 S,Collegeville Rd, Collegeville, PA 19426 USAPhuong Bui - Drexel Univ, Dept Mat Sci & Engn, 3141 Chestnut St, Philadelphia, PA 19104 USAAntonios Zavaliangos - Drexel University
- Publication Details
- AAPS PharmSciTech, v 24(8), pp 237-237
- Publisher
- Springer Nature
- Number of pages
- 11
- Grant note
- P200A150240 / Department of Education; US Department of Education GlaxoSmithKline
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering
- Web of Science ID
- WOS:001107747100005
- Scopus ID
- 2-s2.0-85177574035
- Other Identifier
- 991021811730204721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Pharmacology & Pharmacy