Journal article
Sticking to sugars at the metastatic site: sialyltransferase ST6GalNAc2 acts as a breast cancer metastasis suppressor
Cancer discovery, v 4(3), pp 275-277
Mar 2014
PMID: 24596201
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
O-linked glycans on plasma membrane proteins are altered in cancer cells, leading to changes in cell adhesive properties and contributing to metastasis. Mechanisms of how these carbohydrates alter tumor spread remain vague. In this issue of Cancer Discovery, Murugaesu and colleagues, using an in vivo functional RNA interference metastasis screen, identified sialyltransferase ST6GalNAc2 as a novel metastasis suppressor gene. Aggressive estrogen receptor-negative breast cancers with reduced ST6GalNAc2 expression alter O-linked glycans on tumor cell surface, increasing soluble lectin galectin-3 binding and tumor cell clustering at metastatic sites.
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Details
- Title
- Sticking to sugars at the metastatic site: sialyltransferase ST6GalNAc2 acts as a breast cancer metastasis suppressor
- Creators
- Christina M Ferrer - Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PennsylvaniaMauricio J Reginato
- Publication Details
- Cancer discovery, v 4(3), pp 275-277
- Publisher
- American Association for Cancer Research (AACR); United States
- Grant note
- F31 GM015677 / NIGMS NIH HHS F31 CA183574 / NCI NIH HHS R01 CA155413 / NCI NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000333838600019
- Scopus ID
- 2-s2.0-84895808222
- Other Identifier
- 991014877784504721
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- Web of Science research areas
- Oncology