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Stimulation of the globus pallidus internus in a patient with DYT1-positive primary generalized dystonia: a 10-year follow-up
Journal article   Open access   Peer reviewed

Stimulation of the globus pallidus internus in a patient with DYT1-positive primary generalized dystonia: a 10-year follow-up

Dunbar Alcindor, Michael Y Oh, Susan Baser, Cindy Angle, Boyle C Cheng and Donald Whiting
Neurosurgical focus, v 29(2), pp E16-4
Aug 2010
PMID: 20672918
url
https://doi.org/10.3171/2010.6.FOCUS10112View
Published, Version of Record (VoR) Open

Abstract

Adult Deep Brain Stimulation - methods Dystonia Musculorum Deformans - genetics Dystonia Musculorum Deformans - therapy Dystonic Disorders - therapy Follow-Up Studies Globus Pallidus - physiology Humans Longitudinal Studies Male Molecular Chaperones - genetics Treatment Outcome
The authors report the case of DYT1-positive primary generalized dystonia refractory to medical management that was successfully treated with continuous deep brain stimulation of the internal segment of the globus pallidus. Prior studies have shown that neuromusculoskeletal deficits can remain permanent if early surgical intervention is not undertaken. The authors report prolonged efficacy and safety over a 10-year period in a 28-year-old man.

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Web of Science research areas
Clinical Neurology
Surgery
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