Journal article
Stimulus-driven cerebrospinal fluid dynamics is impaired in glaucoma patients
npj aging, v 12(1), 17
06 Jan 2026
PMID: 41492048
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cerebrospinal fluid (CSF), partly driven by sensory stimulation, is crucial for maintaining homeostasis and clearing metabolic waste. Whether such stimulus-driven CSF flow is disrupted in age-related neurodegenerative diseases of the visual system remains unclear. This study examined the CSF flow during visual stimulation in glaucoma patients and healthy older adults using functional magnetic resonance imaging. In glaucoma, CSF inflow becomes progressively decoupled from the visually evoked blood-oxygenation-level-dependent (BOLD) response. Specifically, the characteristic stimulus-locked CSF patterns, which decrease after stimulus onset and increase after offset, diminish with disease severity. Mediation analysis suggests this flattened CSF pattern is driven by a flatter ascending BOLD slope, leading to a shallower CSF trough and a reduced post-stimulus surge. These results indicate that glaucoma-related functional impairments contribute to downstream alterations in CSF dynamics. Overall, this study provides insight into how glaucoma disrupts visually driven CSF inflow and highlights in vivo biomarkers for monitoring CSF dynamics.
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Details
- Title
- Stimulus-driven cerebrospinal fluid dynamics is impaired in glaucoma patients
- Creators
- Ji Won Bang - New York UniversityCarlos Parra - New York UniversityKevin Yu - New York UniversityHyun Seo Lee - New York UniversityGadi Wollstein - Thomas Jefferson UniversityJoel S. Schuman - Drexel UniversityKevin C. Chan - New York University
- Publication Details
- npj aging, v 12(1), 17
- Publisher
- Nature Publishing
- Number of pages
- 11
- Grant note
- R01-EY028125 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA G2019103 / BrightFocus Foundation Research to Prevent Blindness; Research to Prevent Blindness (RPB)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:001667315900001
- Scopus ID
- 2-s2.0-105028274998
- Other Identifier
- 991022197015704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Geriatrics & Gerontology