Journal article
Stinging insect allergy: Natural history and modification with venom immunotherapy
Journal of allergy and clinical immunology, v 75(6), pp 735-740
01 Jan 1985
PMID: 4008803
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The natural history of stinging insect allergy and its modification by venom immunotherapy was investigated by follow-up observations of patients with histories of venom anaphylaxis and detectable venom-specific IgE. The patients were divided into three categories: (1) receiving venom immunotherapy, (2) declined venom immunotherapy, and (3) terminated venom immunotherapy. One hundred twenty-seven patients were evaluated after 6 mo to 9 yr of venom immunotherapy. Most received top venom doses of 50 μg of yellow jacket and/or honeybee venoms every 4 wk. There were 87 restings in 48 patients resulting in two systemic reactions, only one of which could be considered a treatment failure (1%). Fifty-six patients never received venom immunotherapy. In this group there were 40 restings in 28 patients with 14 systemic reactions (35%). In 88 patients who stopped venom immunotherapy, 61 restings in 41 patients led to 11 systemic reactions (17%). Patients with cardiovascular/or respiratory symptoms with initial sting anaphylaxis were at risk for subsequent reactions. With one exception, patients with hives and edema only as the initial reaction either had a similar or no reaction when they were restung. These results confirm the efficacy of venom immunotherapy but also suggest that there are factors other than the presence of venom-specific IgE modulating the occurrence of clinical anaphylaxis.
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Details
- Title
- Stinging insect allergy: Natural history and modification with venom immunotherapy
- Creators
- Robert E. Reisman - University at Buffalo, State University of New YorkDonald J. Dvorin - University at Buffalo, State University of New YorkChristopher C. Randolph - University at Buffalo, State University of New YorkJohn W. Georgitis - University at Buffalo, State University of New York
- Publication Details
- Journal of allergy and clinical immunology, v 75(6), pp 735-740
- Publisher
- Mosby, Inc
- Number of pages
- 6
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medicine (Graduate)
- Web of Science ID
- WOS:A1985ALA8400018
- Scopus ID
- 2-s2.0-0021823296
- Other Identifier
- 991021930437504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Allergy
- Immunology