Files and links (1)
Published, Version of Record (VoR)Open Access (License Unspecified), Open
Journal article
Strain-specific spleen remodelling in Plasmodium yoelii infections in Balb/c mice facilitates adherence and spleen macrophage-clearance escape
Cellular microbiology, v 13(1), pp 109-122
01 Jan 2011
PMID: 20923452
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Knowledge of the dynamic features of the processes driven by malaria parasites in the spleen is lacking. To gain insight into the function and structure of the spleen in malaria, we have implemented intravital microscopy and magnetic resonance imaging of the mouse spleen in experimental infections with non-lethal (17X) and lethal (17XL)
Plasmodium yoelii
strains. Noticeably, there was higher parasite accumulation, reduced motility, loss of directionality, increased residence time and altered magnetic resonance only in the spleens of mice infected with 17X. Moreover, these differences were associated with the formation of a strain-specific induced spleen tissue barrier of fibroblastic origin, with red pulp macrophage-clearance evasion and with adherence of infected red blood cells to this barrier. Our data suggest that in this reticulocyte-prone non-lethal rodent malaria model, passage through the spleen is different from what is known in other
Plasmodium
species and open new avenues for functional/structural studies of this lymphoid organ in malaria.
Metrics
Details
- Title
- Strain-specific spleen remodelling in Plasmodium yoelii infections in Balb/c mice facilitates adherence and spleen macrophage-clearance escape
- Creators
- Lorena Martin-Jaular - Barcelona Centre for International Health Research, Barcelona, Spain.Mireia Ferrer - Barcelona Centre for International Health Research, Barcelona, Spain.Maria Calvo - University of BarcelonaAnna Rosanas-Urgell - Barcelona Centre for International Health Research, Barcelona, Spain.Susana Kalko - Hospital Clínic de BarcelonaStefanie Graewe - Bernhard Nocht Institute for Tropical MedicineGuadalupe Soria - Spanish National Research CouncilNúria Cortadellas - University of BarcelonaJaume Ordi - Hospital Clínic de BarcelonaAnna Planas - Spanish National Research CouncilJames Burns - Drexel UniversityVolker Heussler - Bernhard Nocht Institute for Tropical MedicineHernando A del Portillo - Institució Catalana de Recerca i Estudis Avançats
- Publication Details
- Cellular microbiology, v 13(1), pp 109-122
- Publisher
- Blackwell Publishing Ltd
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000285756400009
- Scopus ID
- 2-s2.0-78650282788
- Other Identifier
- 991019169445604721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cell Biology
- Microbiology