Journal article
Strategies of Combination Drug Delivery for Immune Checkpoint Blockades
Advanced healthcare materials, v 8(4), pp e1801099-n/a
21 Feb 2019
PMID: 30548835
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The past few years have witnessed vast clinical accomplishments of immune checkpoint blockades (ICB), which block the regulatory receptor expressed on immune cells or tumor cells to prevent the suppression of antitumor cytotoxic T-cell responses. Despite this, limitations still exist, such as low objective response rate (ORR) and the risk of immune-related side effects. To address these issues, combination treatment strategies are vastly explored and recommended. This review summarizes recent advances in combination of ICB with therapies that participate in different stages of cancer immune cycle, including tumor antigen release, tumor antigen presentation, T-cell activation, recognition of cancer cells by T-cells, and tumor-killing activity. Challenges and potential opportunities of combination approaches in this field are also discussed.
Metrics
Details
- Title
- Strategies of Combination Drug Delivery for Immune Checkpoint Blockades
- Creators
- Huitong Ruan - Department of Pharmaceutics School of Pharmacy Key Laboratory of Smart Drug Delivery Fudan University Shanghai 201203 ChinaLinlin Bu - Univ Calif Los Angeles, Dept Bioengn, Los Angeles, CA 90095 USAQuanyin Hu - University of California, Los AngelesHao Cheng - Drexel UniversityWeiyue Lu - Fudan UniversityZhen Gu - University of California, Los Angeles
- Publication Details
- Advanced healthcare materials, v 8(4), pp e1801099-n/a
- Publisher
- Wiley
- Number of pages
- 11
- Grant note
- UCLA; University of California System China Scholarship Council (CSC); China Scholarship Council 81690263 / Jonsson Comprehensive Cancer Center, National Natural Science Foundation of China
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering
- Web of Science ID
- WOS:000460697200004
- Scopus ID
- 2-s2.0-85058476706
- Other Identifier
- 991019169700304721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials
- Nanoscience & Nanotechnology