Logo image
Strategies of Combination Drug Delivery for Immune Checkpoint Blockades
Journal article

Strategies of Combination Drug Delivery for Immune Checkpoint Blockades

Huitong Ruan, Linlin Bu, Quanyin Hu, Hao Cheng, Weiyue Lu and Zhen Gu
Advanced healthcare materials, v 8(4), pp e1801099-n/a
21 Feb 2019
PMID: 30548835

Abstract

Engineering Engineering, Biomedical Materials Science Materials Science, Biomaterials Nanoscience & Nanotechnology Science & Technology Science & Technology - Other Topics Technology
The past few years have witnessed vast clinical accomplishments of immune checkpoint blockades (ICB), which block the regulatory receptor expressed on immune cells or tumor cells to prevent the suppression of antitumor cytotoxic T-cell responses. Despite this, limitations still exist, such as low objective response rate (ORR) and the risk of immune-related side effects. To address these issues, combination treatment strategies are vastly explored and recommended. This review summarizes recent advances in combination of ICB with therapies that participate in different stages of cancer immune cycle, including tumor antigen release, tumor antigen presentation, T-cell activation, recognition of cancer cells by T-cells, and tumor-killing activity. Challenges and potential opportunities of combination approaches in this field are also discussed.

Metrics

11 Record Views
38 citations in Scopus

Details

UN Sustainable Development Goals (SDGs)

This publication has contributed to the advancement of the following goals:

#3 Good Health and Well-Being

InCites Highlights

Data related to this publication, from InCites Benchmarking & Analytics tool:

Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Engineering, Biomedical
Materials Science, Biomaterials
Nanoscience & Nanotechnology
Logo image