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Strategies to reduce perioperative acute kidney injury in non-cardiac adult surgeries: the secret sauce
Journal article   Peer reviewed

Strategies to reduce perioperative acute kidney injury in non-cardiac adult surgeries: the secret sauce

Shu Zhao, Jackie Zhao and Megan Rashid
Journal of the National Medical Association, v 118(2), pp 190-194
01 Apr 2026
PMID: 41720712
Featured in Collection :   Drexel's Newest Publications

Abstract

Acute kidney injury Artificial intelligence Novel biomarkers Perioperative optimization
Acute kidney injury is a common perioperative complication that leads to significant downstream effects on the patient and the health system. Patients regularly present for surgery with several risk factors for AKI, but we have not yet determined the optimal method of risk stratification or strategy for prevention of AKI. This paper provides a review of the latest literature on perioperative considerations for anesthesiologists when evaluating and treating patients at higher risk for postoperative kidney injury. The ADQI/PQI recommends a kidney health assessment before surgery, focusing on optimizing preoperative risk factors in patients before surgery. Using goal-directed hemodynamic therapy, incorporating volume status, blood pressure, and cardiac output monitoring to optimize volume status in high-risk patients and using renoprotective medications could further reduce the risk of AKI. We’ve highlighted some interesting research regarding novel biomarkers and artificial intelligence/machine learning. Promising research is ongoing in this sector, but much work still needs to be done.

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