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Stress-induced redistribution of corticotropin-releasing factor receptor subtypes in the dorsal raphe nucleus
Journal article   Open access   Peer reviewed

Stress-induced redistribution of corticotropin-releasing factor receptor subtypes in the dorsal raphe nucleus

Maria Waselus, Cristiano Nazzaro, Rita J Valentino and Elisabeth J Van Bockstaele
Biological psychiatry (1969), v 66(1), pp 76-83
01 Jul 2009
DOI: https://doi.org/10.1016/j.biopsych.2009.02.014
PMID: 19362706
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://europepmc.org/articles/pmc2728006View
Accepted (AM)Open Access (License Unspecified),  Open

Abstract

Action Potentials - physiology Animals Behavior, Animal Disease Models, Animal Male Microscopy, Immunoelectron - methods Neurons - physiology Neurons - ultrastructure Protein Transport Raphe Nuclei - metabolism Raphe Nuclei - pathology Raphe Nuclei - physiopathology Rats Rats, Sprague-Dawley Receptors, Corticotropin-Releasing Hormone - metabolism Serotonin - metabolism Stress, Psychological - pathology Swimming
The stress-related neuropeptide corticotropin-releasing factor (CRF) is involved in determining behavioral strategies for responding to stressors, in part through its regulation of the dorsal raphe (DR)-serotonin (5-HT) system. CRF(1) and CRF(2) receptor subtypes have opposing effects on this system that are associated with active versus passive coping strategies, respectively. Immunoelectron microscopy and in vivo single-unit recordings were used to assess CRF receptor distribution and neuronal responses, respectively, in the DR of stressed and unstressed rats. Here we show that in unstressed rats CRF(1) and CRF(2) are differentially distributed within DR cells, with CRF(1) being prominent on the plasma membrane and CRF(2) being cytoplasmic. Stress experience reverses this distribution, such that CRF(2) is recruited to the plasma membrane and CRF(1) tends to internalize. As a consequence of this stress-induced cellular redistribution of CRF receptors, neuronal responses to CRF change from inhibition to a CRF(2)-mediated excitation. Given evidence that CRF(1) and CRF(2) activation are associated with distinct behavioral responses to stress, the stress-triggered reversal in receptor localization provides a cellular mechanism for switching behavioral strategies for coping with stressors.

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107 citations in Web of Science
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Collaboration types
Domestic collaboration
Web of Science research areas
Neurosciences
Psychiatry
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