Journal article
Stress-induced senescence in human and rodent astrocytes
Experimental cell research, v 316(17), pp 2961-2968
15 Oct 2010
PMID: 20620137
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
There is an increasing awareness that astrocytes, the most abundant cell type in the central nervous system, are critical mediators of brain homeostasis, playing multifunctional roles including buffering potassium ions, maintaining the blood-brain barrier, releasing growth factors, and regulating neurotransmitter levels. Defects in astrocyte function have been implicated in a variety of diseases including age-related diseases such Alzheimer's disease and Parkinson's disease. However, little is known about the age-related changes that occur in astrocytes and if these cells are able to generate a senescent phenotype in response to stress. In this report we have examined whether astrocytes can initiate a senescence program similar to that described in other cell types in response to a variety of stresses. Our results indicate that after oxidative stress, proteasome inhibition, or exhausted replication, human and mouse astrocytes show changes in several established markers of cellular senescence. Astrocytes appear to be more sensitive to oxidative stress than fibroblasts, suggesting that stress-induced senescence may be more pronounced in the brain than in other tissues. (C) 2010 Elsevier Inc. All rights reserved.
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Details
- Title
- Stress-induced senescence in human and rodent astrocytes
- Creators
- Alessandro Bitto - Drexel UniversityChristian Sell - Drexel UniversityElizabeth Crowe - Drexel UniversityAntonello Lorenzini - Drexel UniversityMarco Malaguti - University of BolognaSilvana Hrelia - University of BolognaClaudio Torres - Drexel University
- Publication Details
- Experimental cell research, v 316(17), pp 2961-2968
- Publisher
- Elsevier
- Number of pages
- 8
- Grant note
- R01AG022443 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) AG022443; AG022443-S1 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology; Neurobiology and Anatomy; Pathology (and Laboratory Medicine)
- Web of Science ID
- WOS:000282357300023
- Scopus ID
- 2-s2.0-77956875648
- Other Identifier
- 991019168177404721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cell Biology
- Oncology