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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Stress-induced suppression of hippocampal neurogenesis in adult male rats is altered by prenatal ethanol exposure
Stress (Amsterdam, Netherlands), v 13(4), pp 302-314
01 Jul 2010
PMID: 20536332
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
In adulthood, both alcohol ( ethanol) and stress are known to suppress hippocampal neurogenesis in male rats. Similarly, most studies report that prenatal alcohol exposure (PAE) reduces cell proliferation and/or cell survival in the hippocampus of adult males. Furthermore, PAE is known to have marked effects on behavioral and hypothalamic-pituitary-adrenal (HPA) responsiveness to stressors. However, no studies have examined the modulation of adult hippocampal neurogenesis by stress in PAE animals. We hypothesized that, in accordance with previous data, PAE would suppress basal levels of adult hippocampal neurogenesis, and further that stress acting on a sensitized HPA axis would have greater adverse effects on adult hippocampal neurogenesis in PAE than in control rats.
Adult male offspring from PAE, pair-fed (PF) control, and ad libitum-fed control (C) groups were subjected to restraint stress (9 days, 1 h/day) or left undisturbed. Rats were then injected with bromodeoxyuridine (BrdU) on day 10, perfused 24 h (proliferation) or 3 weeks (survival) later, and brains processed for BrdU immunohistochemistry. We found that (1) under non-stressed conditions, PAE rats had a small but statistically significant suppressive effect on levels of hippocampal neurogenesis and (2) unexpectedly, repeated restraint stress significantly reduced neurogenesis in C and PF, but not PAE rats. We speculate that the failure of PAE males to mount an appropriate (i.e. suppressive) neurogenic response to stressors, implies reduced plasticity and adaptability or resilience, which could impact negatively on hippocampal structure and function.
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Details
- Title
- Stress-induced suppression of hippocampal neurogenesis in adult male rats is altered by prenatal ethanol exposure
- Creators
- J. H. Sliwowska - University of British ColumbiaJ. M. Barker - University of British ColumbiaC. K. Barha - University of British ColumbiaN. Lan - University of British ColumbiaJ. Weinberg - University of British ColumbiaL. A. M. Galea - University of British Columbia
- Publication Details
- Stress (Amsterdam, Netherlands), v 13(4), pp 302-314
- Publisher
- Taylor & Francis
- Number of pages
- 13
- Grant note
- Ministry of Children and Family Development AA007789 / NIH/NIAAA; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Alcohol Abuse & Alcoholism (NIAAA) IMPART CIHR; Canadian Institutes of Health Research (CIHR) NSERC PGS scholarships R37AA007789 / NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Alcohol Abuse & Alcoholism (NIAAA) BC Ministry of Children and Family Development
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- College of Medicine; Pharmacology and Physiology; Drexel University
- Web of Science ID
- WOS:000280146300003
- Scopus ID
- 2-s2.0-77953456446
- Other Identifier
- 991020111279504721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Behavioral Sciences
- Endocrinology & Metabolism
- Neurosciences