Journal article
Structural Analysis of Anesthetics in Complex with Soluble Proteins
Methods in enzymology, v 603, pp 3-20
2018
PMID: 29673532
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Anesthetics interact with a broad range of different targets, including both soluble and membrane-bound proteins. Understanding these interactions at the molecular level requires detailed structural knowledge of anesthetic-protein complexes, and one of the most productive routes to such knowledge is X-ray crystallography. In this chapter we discuss the application of this technique to the analysis of complexes of anesthetics with soluble proteins. The model protein apoferritin is highlighted, and protocols are presented for obtaining diffraction-quality crystals of this protein in complex with different general anesthetics.
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Details
- Title
- Structural Analysis of Anesthetics in Complex with Soluble Proteins
- Creators
- Patrick J Loll - Drexel University
- Publication Details
- Methods in enzymology, v 603, pp 3-20
- Publisher
- Elsevier
- Grant note
- P01 GM055876 / NIGMS NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Biochemistry and Molecular Biology
- Web of Science ID
- WOS:000436629500002
- Scopus ID
- 2-s2.0-85042566132
- Other Identifier
- 0128145749; 9780128145746; 991019170503504721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Anesthesiology
- Biochemical Research Methods
- Biochemistry & Molecular Biology