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Published, Version of Record (VoR)CC BY-NC-ND V4.0, Open
Journal article
Structural disconnection of the posterior medial frontal cortex reduces speech error monitoring
NeuroImage clinical, v 33, pp 102934-102934
2022
PMID: 34995870
Abstract
Optimal performance in any task relies on the ability to detect and correct errors. The anterior cingulate cortex and the broader posterior medial frontal cortex (pMFC) are active during error processing. However, it is unclear whether damage to the pMFC impairs error monitoring. We hypothesized that successful error monitoring critically relies on connections between the pMFC and broader cortical networks involved in executive functions and the task being monitored. We tested this hypothesis in the context of speech error monitoring in people with post-stroke aphasia. Diffusion weighted images were collected in 51 adults with chronic left-hemisphere stroke and 37 age-matched control participants. Whole-brain connectomes were derived using constrained spherical deconvolution and anatomically-constrained probabilistic tractography. Support vector regressions identified white matter connections in which lost integrity in stroke survivors related to reduced error detection during confrontation naming. Lesioned connections to the bilateral pMFC were related to reduce error monitoring, including many connections to regions associated with speech production and executive function. We conclude that connections to the pMFC support error monitoring. Error monitoring in speech production is supported by the structural connectivity between the pMFC and regions involved in speech production, comprehension, and executive function. Interactions between pMFC and other task-relevant processors may similarly be critical for error monitoring in other task contexts.
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Details
- Title
- Structural disconnection of the posterior medial frontal cortex reduces speech error monitoring
- Creators
- Joshua D McCall - Georgetown University Medical CenterJ Vivian Dickens - Center for Brain Plasticity and Recovery and Neurology Department, Georgetown University Medical Center, Washington, DC 20007, USAAyan S Mandal - Georgetown University Medical CenterAndrew T DeMarco - Georgetown University Medical CenterMackenzie E Fama - Center for Brain Plasticity and Recovery and Neurology Department, Georgetown University Medical Center, Washington, DC 20007, USA; Department of Speech, Language, and Hearing Sciences, The George Washington University, DC 20052, USAElizabeth H Lacey - MedStar National Rehabilitation HospitalApoorva Kelkar - Drexel UniversityJohn D Medaglia - Drexel UniversityPeter E Turkeltaub - Georgetown University Medical Center
- Publication Details
- NeuroImage clinical, v 33, pp 102934-102934
- Publisher
- Elsevier
- Grant note
- F30 DC018215 / NIDCD NIH HHS K12 HD093427 / NICHD NIH HHS U10 NS086513 / NINDS NIH HHS R21 DE014960 / NIDCR NIH HHS F31 DC014875 / NIDCD NIH HHS K99 DC018828 / NIDCD NIH HHS F30 DC019024 / NIDCD NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000744079400002
- Scopus ID
- 2-s2.0-85122338729
- Other Identifier
- 991019168033004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neuroimaging