Journal article
Structure, properties, and bioactivity of 3D printed PAEKs for implant applications: A systematic review
Journal of biomedical materials research. Part B, Applied biomaterials, v 109(11), pp 1924-1941
Nov 2021
PMID: 33856114
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Additive manufacturing (AM) of high temperature polymers, specifically polyaryletherketones (PAEK), is gaining significant attention for medical implant applications. As 3D printing systems evolve toward point of care manufacturing, research on this topic continues to expand. Specific regulatory guidance is being developed for the safe management of 3D printing systems in a hospital environment. PAEK implants can benefit from many advantages of AM such as design freedom, material and antibacterial drug incorporation, and enhanced bioactivity provided by cancellous bone-like porous designs. In addition to AM PAEK bioactivity, the biomechanical strength of 3D printed implants is crucial to their performance and thus widely studied. In this review, we discuss the printing conditions that have been investigated so far for additively manufactured PAEK implant applications. The effect of processing parameters on the biomechanical strength of implants is summarized, and the bioactivity of PAEKs, along with material and drug incorporation, is also covered in detail. Finally, the therapeutic areas in which 3D printed PAEK implants are investigated and utilized are reviewed.
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Details
- Title
- Structure, properties, and bioactivity of 3D printed PAEKs for implant applications: A systematic review
- Creators
- Cemile Basgul - Drexel UniversityHannah Spece - Drexel UniversityNeha Sharma - University Hospital of BaselFlorian M Thieringer - University Hospital of BaselSteven M Kurtz - Exponent (United States)
- Publication Details
- Journal of biomedical materials research. Part B, Applied biomaterials, v 109(11), pp 1924-1941
- Publisher
- Wiley
- Grant note
- R01-AR069119 / NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000640231200001
- Scopus ID
- 2-s2.0-85104333636
- Other Identifier
- 991019168342604721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials