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Journal article
Studies of androgen production and binding in 13 male pseudohermaphrodites and 13 males with micropenis
The journal of clinical endocrinology and metabolism, v 45(4), pp 732-738
Oct 1977
PMID: 914979
Abstract
We studied androgen production by morphologic and biochemical criteria plus androgen binding by skin fibroblasts in 13 male pseudo-hermaphrodites and 13 males with micropenis, none of whom had evidence of androgen insensitivity. Seventeen of the 26 patients had evidence of deficient androgen production, suggesting this as the cause of their incomplete virilization in utero. Fibroblasts from all 26 patients demonstrated normal androgen binding and affinity of the steroid for the receptor. Although these results exclude a deficiency of androgen binding in these individuals, other end organ defects are possible. Guidelines for diagnosis and management of such patients are presented. (J Clin Endocrinol Metab 45: 732, 1977)
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Details
- Title
- Studies of androgen production and binding in 13 male pseudohermaphrodites and 13 males with micropenis
- Creators
- James A. Amrhein - Johns Hopkins UniversityWalter J. Meyer - Johns Hopkins UniversityRobert K. Danish - Johns Hopkins UniversityClaude J. Migeon - Johns Hopkins University
- Publication Details
- The journal of clinical endocrinology and metabolism, v 45(4), pp 732-738
- Publisher
- ENDOCRINE SOC
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:A1977DY82200019
- Scopus ID
- 2-s2.0-0017689493
- Other Identifier
- 991021463692704721