Journal article
Studies of in vitro asbestos-cell interaction
Journal of environmental pathology and toxicology, v 2(4), pp 1029-1039
Mar 1979
PMID: 448250
Abstract
Using amosite and chrysotile, asbestos cytotoxicity is shown to be a function of time and is abolished by filtration of the culture medium containing asbestos fibers through a 0.2-micrometer filter. There is evidence that cytotoxicity is related to the phagocytic property of cells since non-phagocytic fibroblasts survive under conditions lethal to P388D1 cells. Time lapse studies show that apparently normal mitosis occurs in the presence of intracellular asbestos, but the presence of fibers in sufficient quantity results in cytotoxicity. Effects on human (WI-38) fibroblasts are also reported.
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Details
- Title
- Studies of in vitro asbestos-cell interaction
- Creators
- M J WadeL E LipkinA L Frank
- Publication Details
- Journal of environmental pathology and toxicology, v 2(4), pp 1029-1039
- Publisher
- United States
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Environmental and Occupational Health
- Web of Science ID
- WOS:A1979GT78600008
- Scopus ID
- 2-s2.0-0018647579
- Other Identifier
- 991014878347004721