Journal article
Study of an ovarian sclerosing stromal tumor presenting as vaginal bleeding in a 7-month-old
Pediatric and developmental pathology, v 11(4)
01 Jul 2008
PMID: 17990931
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
This communication describes the histological, immunohistochemical, ultrastructural, and cytogenetic study of an ovarian sclerosing stromal tumor resected from a 7-month-old girl who presented with vaginal bleeding. The tumor is very rare, its pathogenesis is not clear, and its hormonal activity has been subject to debate. In addition, it has been rarely seen in children and never in infants, with the youngest patient reported being 10 years of age. Histological Study of the tumor showed a process of multinodular asynchronous growth followed by gradual loss of cells, hyalinization, and eventual transformation into corpora albicantia-like structures, thus indicating that the process may be more akin to an ovarian nodular follicular hyperplasia than to a classical neoplasm. The Study also documented an elevated proliferative MIB-1 index in the process, which had not been investigated in earlier reports, and illustrated the immunohistochemical reactivity of some of its stromal cells to progesterone receptors.
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Details
- Title
- Study of an ovarian sclerosing stromal tumor presenting as vaginal bleeding in a 7-month-old
- Creators
- Odette R. Hall - St. Christopher's Hospital for ChildrenJudy M. Pascasio - Drexel UniversityJennifer J. Morrissette - Drexel UniversityChristopher Newton - St. Christopher's Hospital for ChildrenMarshall Z. Schwartz - Drexel UniversityJean-Pierre de Chadarevian - Drexel University
- Publication Details
- Pediatric and developmental pathology, v 11(4)
- Publisher
- Sage
- Number of pages
- 5
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000259353300008
- Scopus ID
- 2-s2.0-53549083227
- Other Identifier
- 991019169104504721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Pathology
- Pediatrics