Journal article
Subcellular Communication Through RNA Transport and Localized Protein Synthesis
Traffic (Copenhagen, Denmark), v 11(12), pp 1498-1505
Dec 2010
PMID: 21040295
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Interest in the mechanisms of subcellular localization of mRNAs and the effects of localized translation has increased over the last decade. Polarized eukaryotic cells transport mRNA-protein complexes to subcellular sites, where translation of the mRNAs can be regulated by physiological stimuli. The long distances separating distal neuronal processes from their cell body have made neurons a useful model system for dissecting mechanisms of mRNA trafficking. Both the dendritic and axonal processes of neurons have been shown to have protein synthetic capacity and the diversity of mRNAs discovered in these processes continues to increase. Localized translation of mRNAs requires a co-ordinated effort by the cell body to target both mRNAs and necessary translational machinery into distal sites, as well as temporal control of individual mRNA translation. In addition to altering protein composition locally at the site of translation, some of the proteins generated in injured nerves retrogradely signal to the cell body, providing both temporal and spatial information on events occurring at distant subcellular sites.
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Details
- Title
- Subcellular Communication Through RNA Transport and Localized Protein Synthesis
- Creators
- Christopher J. Donnelly - University of DelawareMike Fainzilber - Weizmann Institute of ScienceJeffery L. Twiss - Drexel University
- Publication Details
- Traffic (Copenhagen, Denmark), v 11(12), pp 1498-1505
- Publisher
- Wiley
- Number of pages
- 8
- Grant note
- R01NS049041 / NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Neurological Disorders & Stroke (NINDS) Minerva Foundation University of Delaware R01-NS041596; R01-NS049041 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA International Institute for Research in Paraplegia Miriam and Sheldon Adelson Medical Research Foundation Christopher and Dana Reeve Foundation Israel Science Foundation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000284167700004
- Scopus ID
- 2-s2.0-78349254943
- Other Identifier
- 991021892107004721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Cell Biology