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Journal article
Subgraphs of functional brain networks identify dynamical constraints of cognitive control
PLoS computational biology, v 14(7), pp e1006234-e1006234
01 Jul 2018
PMCID: PMC6056061
PMID: 29979673
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Brain anatomy and physiology support the human ability to navigate a complex space of perceptions and actions. To maneuver across an ever-changing landscape of mental states, the brain invokes cognitive control-a set of dynamic processes that engage and disengage different groups of brain regions to modulate attention, switch between tasks, and inhibit prepotent responses. Current theory posits that correlated and anticorrelated brain activity may signify cooperative and competitive interactions between brain areas that subserve adaptive behavior. In this study, we use a quantitative approach to identify distinct topological motifs of functional interactions and examine how their expression relates to cognitive control processes and behavior. In particular, we acquire fMRI BOLD signal in twenty-eight healthy subjects as they perform two cognitive control tasks-a Stroop interference task and a local-global perception switching task using Navon figures-each with low and high cognitive control demand conditions. Based on these data, we construct dynamic functional brain networks and use a parts-based, network decomposition technique called nonnegative matrix factorization to identify putative cognitive control subgraphs whose temporal expression captures distributed network structures involved in different phases of cooperative and competitive control processes. Our results demonstrate that temporal expression of the subgraphs fluctuate alongside changes in cognitive demand and are associated with individual differences in task performance. These findings offer insight into how coordinated changes in the cooperative and competitive roles of cognitive systems map trajectories between cognitively demanding brain states.
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Details
- Title
- Subgraphs of functional brain networks identify dynamical constraints of cognitive control
- Creators
- Ankit N. Khambhati - University of PennsylvaniaJohn D. Medaglia - Drexel UniversityElisabeth A. Karuza - University of PennsylvaniaSharon L. Thompson-Schill - University of PennsylvaniaDanielle S. Bassett - University of Pennsylvania
- Publication Details
- PLoS computational biology, v 14(7), pp e1006234-e1006234
- Publisher
- Public Library Science
- Number of pages
- 33
- Grant note
- Paul G. Allen Foundation W911NF-14-1-0679; W911NF-16-1-0474 / Army Research Office Office of Naval Research 2-R01-DC-009209-11; 1R01HD086888-01; R01-MH107235; R01-MH107703; R01MH109520; 1R01NS099348; R21-M MH-106799 / National Institute of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA BCS-1441502; CAREER PHY-1554488; BCS-1631550; CNS-1626008 / National Science Foundation; National Science Foundation (NSF) Alfred P. Sloan Foundation W911NF-10-2-0022 / Army Research Laboratory; United States Department of Defense; US Army Research Laboratory (ARL) John D. and Catherine T. MacArthur Foundation R01DC009209 / NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Deafness & Other Communication Disorders (NIDCD)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Psychological and Brain Sciences (Psychology)
- Web of Science ID
- WOS:000440483300008
- Scopus ID
- 2-s2.0-85050960757
- Other Identifier
- 991019168345704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemical Research Methods
- Mathematical & Computational Biology