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Subharmonic microbubble emissions for noninvasively tracking right ventricular pressures
Journal article   Open access   Peer reviewed

Subharmonic microbubble emissions for noninvasively tracking right ventricular pressures

Jaydev K. Dave, Valgerdur G. Halldorsdottir, John R. Eisenbrey, Joel S. Raichlen, Ji-Bin Liu, Maureen E. McDonald, Kris Dickie, Shumin Wang, Corina Leung and Flemming Forsberg
American journal of physiology. Heart and circulatory physiology, v 303(1), pp H126-H132
04 May 2012
DOI: https://doi.org/10.1152/ajpheart.00560.2011
PMID: 22561300
Featured in Collection :   UN Sustainable Development Goals @ Drexel
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https://doi.org/10.1152/ajpheart.00560.2011View
Published, Version of Record (VoR)Open Access (License Unspecified),  Open

Abstract

contrast echocardiography contrast media Integrative Cardiovascular Physiology and Pathophysiology noninvasive pressure estimation subharmonic microbubble signals
Right heart catheterization is often required to monitor intra-cardiac pressures in a number of disease states. Ultrasound contrast agents can produce pressure modulated subharmonic emissions that may be used to estimate right ventricular (RV) pressures. A technique based on subharmonic acoustic emissions from ultrasound contrast agents to track RV pressures noninvasively has been developed and its clinical potential evaluated. The subharmonic signals were obtained from the aorta, RV, and right atrium (RA) of five anesthetized closed-chest mongrel dogs using a SonixRP ultrasound scanner and PA4-2 phased array. Simultaneous pressure measurements were obtained using a 5-French solid state micromanometer tipped catheter. Initially, aortic subharmonic signals and systemic blood pressures were used to obtain a calibration factor in units of millimeters of mercury per decibel. This factor was combined with RA pressures (that can be obtained noninvasively) and the acoustic data from the RV to obtain RV pressure values. The individual calibration factors ranged from −2.0 to −4.0 mmHg/dB. The subharmonic signals tracked transient changes in the RV pressures within an error of 0.6 mmHg. Relative to the catheter pressures, the mean errors in estimating RV peak systolic and minimum diastolic pressures, and RV relaxation [isovolumic negative derivative of change in pressure over time (−dP/d t )] by use of the subharmonic signals, were −2.3 mmHg, −0.8 mmHg, and 2.9 mmHg/s, respectively. Overall, acoustic estimates of RV peak systolic and minimum diastolic pressures and RV relaxation were within 3.4 mmHg, 1.8 mmHg, and 5.9 mmHg/s, respectively, of the measured pressures. This pilot study demonstrates that subharmonic emissions from ultrasound contrast agents have the potential to noninvasively track in vivo RV pressures with errors below 3.5 mmHg.

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31 citations in Web of Science
32 citations in Scopus

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Collaboration types
Domestic collaboration
International collaboration
Web of Science research areas
Cardiac & Cardiovascular Systems
Peripheral Vascular Disease
Physiology
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