Journal article
Subjective and Objective Measurements of Sinonasal Manifestations in Patients With Autoimmune Disorders
The Laryngoscope, v 131(2)
Feb 2021
PMID: 32324298
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objectives/Hypothesis
A number of autoimmune disorders (ADs) are associated with a spectrum of sinonasal manifestations comparable to chronic rhinosinusitis (CRS). Our objective was to study the subjective and objective measurements of sinonasal manifestations of ADs.
Study Design
Retrospective cohort study.
Methods
All patients with ADs referred to our tertiary care rhinology clinic from 2008 to 2019 with sinonasal symptoms were compared to randomly selected cohorts of noneosinophilic CRS without nasal polyps (neCRSsNP) and eosinophilic CRSsNP (eCRSsNP). Demographic data, along with the 22‐item Sino‐Nasal Outcome Test (SNOT‐22), Lund‐Kennedy (LK) endoscopy score, Lund‐Mackay (LM) computed tomography (CT) score, nasal crusting, and epistaxis were reviewed at presentation.
Results
Fifty‐three patients with an AD (26 with sarcoidosis, 14 with systemic lupus erythematosus, 10 with granulomatosis with polyangiitis [GPA], and three with pemphigoid vulgaris) were identified, and compared to 75 randomly selected neCRSsNP patients and 75 eCRSsNP patients. Patients with an AD had an average SNOT‐22 score of 44.4 (confidence interval [CI]: 34.6‐51.2) compared to 25 (CI: 24.4‐25.1) and 29.7 (CI: 20.3‐29.7) for neCRSsNP and eCRSsNP patients, respectively (P < .0001), and an average LK endoscopy score of 5.3 (CI: 4.3‐6.3), compared to 3.4 (P = .005, CI: 2.7‐4) in neCRSsNP and 4.4 in eCRSsNP (P = .2, CI: 3.7‐5). There was no significant difference in the CT score compared to both groups. Patients with an AD also scored significantly worse on all four SNOT‐33 subdomains, nasal obstruction, nasal crusting, and epistaxis. Additionally, patients with GPA had the worst symptomatic and endoscopy scores.
Conclusions
Patients with ADs presenting with sinonasal symptoms have a more severe subjective and objective presentation than patients with CRS without nasal polyps.
Level of Evidence
4 Laryngoscope, 131:255–259, 2021
Metrics
Details
- Title
- Subjective and Objective Measurements of Sinonasal Manifestations in Patients With Autoimmune Disorders
- Creators
- Chadi A. Makary - Augusta UniversityBrittany Gill - Augusta UniversityBrock Parman - Augusta UniversityAykut A. Unsal - Drexel UniversityThomas Holmes - Augusta UniversityCamilo Reyes‐Gelves - Augusta UniversityStilianos E. Kountakis - Augusta University
- Publication Details
- The Laryngoscope, v 131(2)
- Publisher
- John Wiley & Sons, Inc
- Number of pages
- 5
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Otolaryngology (and Head and Neck Surgery)
- Web of Science ID
- WOS:000527855200001
- Scopus ID
- 2-s2.0-85084058479
- Other Identifier
- 991019168470204721
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InCites Highlights
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Medicine, Research & Experimental
- Otorhinolaryngology