Journal article
Substance P in the anterior thalamic paraventricular nucleus: promotion of ethanol drinking in response to orexin from the hypothalamus
Addiction biology, v 22(1), pp 58-69
Jan 2017
PMID: 26223289
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The paraventricular nucleus of the thalamus (PVT) appears to participate in drug addiction. Recent evidence in rats shows that ethanol drinking is increased by orexin/hypocretin (OX) afferents from the hypothalamus, acting specifically in the anterior (aPVT) rather than posterior (pPVT) PVT subregion. The present study sought to identify neuropeptides transcribed within the PVT, which themselves might contribute to ethanol drinking and possibly mediate the actions of OX. We discovered that substance P (SP) in the aPVT can stimulate intermittent-access ethanol drinking, similar to OX, and that SP receptor [neurokinin 1 receptor/tachykinin receptor 1 (NK1R)] antagonists in this subregion reduce ethanol drinking. As with OX, this effect is site specific, with SP in the pPVT or dorsal third ventricle having no effect on ethanol drinking, and it is behaviorally specific, with SP in the aPVT reducing the drinking of sucrose and stimulating it in the pPVT. A close relationship between SP and OX was demonstrated by a stimulatory effect of local OX injection on SP mRNA and peptide levels, specifically in the aPVT but not pPVT, and a stimulatory effect of OX on SP expression in isolated thalamic neurons, reflecting postsynaptic actions. A functional relationship between OX and SP in the aPVT is suggested by our additional finding that ethanol drinking induced by OX is blocked by a local NK1R antagonist administered at a sub-threshold dose. These results, suggesting that SP in the aPVT mediates the stimulatory effect of OX on ethanol drinking, identify a new role for SP in the control of this behavior.
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Details
- Title
- Substance P in the anterior thalamic paraventricular nucleus: promotion of ethanol drinking in response to orexin from the hypothalamus
- Creators
- Jessica R Barson - Drexel UniversityKinning Poon - Rockefeller UniversityHui Tin Ho - Rockefeller UniversityMohammad I Alam - Rockefeller UniversityLilia Sanzalone - Rockefeller UniversitySarah F Leibowitz - Rockefeller University
- Publication Details
- Addiction biology, v 22(1), pp 58-69
- Publisher
- Wiley
- Grant note
- UL1 TR000043 / NCATS NIH HHS K99 AA021782 / NIAAA NIH HHS R01 AA012882 / NIAAA NIH HHS R01 AA024798 / NIAAA NIH HHS F32 DK100058 / NIDDK NIH HHS R00 AA021782 / NIAAA NIH HHS
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000393902700004
- Scopus ID
- 2-s2.0-84938150808
- Other Identifier
- 991019168309704721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Substance Abuse