Journal article
Substance abuse, HIV-1 and hepatitis
Current HIV research, v 10(7), pp 557-571
Oct 2012
PMID: 22973853
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
During the course of human immunodeficiency virus type 1 (HIV-1) disease, the virus has been shown to effectively escape the immune response with the subsequent establishment of latent viral reservoirs in specific cell populations within the peripheral blood (PB) and associated lymphoid tissues, bone marrow (BM), brain, and potentially other end organs. HIV-1, along with hepatitis B and C viruses (HBV and HCV), are known to share similar routes of transmission, including intravenous drug use, blood transfusions, sexual intercourse, and perinatal exposure. Substance abuse, including the use of opioids and cocaine, is a significant risk factor for exposure to HIV-1 and the development of acquired immune deficiency syndrome, as well as HBV and HCV exposure, infection, and disease. Thus, coinfection with HIV-1 and HBV or HCV is common and may be impacted by chronic substance abuse during the course of disease. HIV-1 impacts the natural course of HBV and HCV infection by accelerating the progression of HBV/HCV-associated liver disease toward end-stage cirrhosis and quantitative depletion of the CD4
+
T-cell compartment. HBV or HCV coinfection with HIV-1 is also associated with increased mortality when compared to either infection alone. This review focuses on the impact of substance abuse and coinfection with HBV and HCV in the PB, BM, and brain on the HIV-1 pathogenic process as it relates to viral pathogenesis, disease progression, and the associated immune response during the course of this complex interplay. The impact of HIV-1 and substance abuse on hepatitis virus-induced disease is also a focal point.
Metrics
Details
- Title
- Substance abuse, HIV-1 and hepatitis
- Creators
- Nirzari Parikh - Department of Microbiology and Immunology Drexel University College of Medicine Philadelphia, Pennsylvania 19102, USAMichael R Nonnemacher - Department of Microbiology and Immunology Drexel University College of Medicine Philadelphia, Pennsylvania 19102, USAVanessa Pirrone - Department of Microbiology and Immunology Drexel University College of Medicine Philadelphia, Pennsylvania 19102, USATimothy Block - Department of Microbiology and Immunology Drexel University College of Medicine Philadelphia, Pennsylvania 19102, USAAnand Mehta - Department of Microbiology and Immunology Drexel University College of Medicine Philadelphia, Pennsylvania 19102, USABrian Wigdahl - Department of Microbiology and Immunology Drexel University College of Medicine Philadelphia, Pennsylvania 19102, USA
- Publication Details
- Current HIV research, v 10(7), pp 557-571
- Publisher
- Bentham
- Grant note
- R01 DA019807 || DA / National Institute on Drug Abuse : NIDA
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Microbiology and Immunology
- Web of Science ID
- WOS:000311105700001
- Scopus ID
- 2-s2.0-84867629494
- Other Identifier
- 991014878062604721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Immunology
- Infectious Diseases
- Virology