Journal article
Successful Treatment of Acute Severe Graft-Versus-Host-Disease in a Pancreas-After-Kidney Transplant Recipient: Case Report
Transplantation proceedings, v 46(7), pp 2446-2449
01 Sep 2014
PMID: 25179161
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The development of acute graft-versus-host-disease (GVHD) in recipients of pancreas transplants is a rare and quite often a fatal post-transplantation complication. We present a 38-year-old male with a longstanding history of type 1 diabetes mellitus and end-stage kidney disease, with a living unrelated kidney transplant from his wife for 3 years, who received an enteric-drained 5-antigen HLA mismatched deceased-donor pancreas. Five weeks after transplantation, he presented with spiking fevers, severe skin rash, diarrhea, pancytopenia, and increasingly abnormal liver function tests. Skin biopsies were consistent with grade 3 acute GVHD. The patient was treated for GVHD with escalated doses of tacrolimus, pulse doses of steroids, and basiliximab. He was discharged after a 4-week hospital stay with complete resolution of his rash, fever, abnormal liver enzymes, and leukopenia. He remained in good health with excellent kidney and pancreas allograft function 3 years later.
Metrics
Details
- Title
- Successful Treatment of Acute Severe Graft-Versus-Host-Disease in a Pancreas-After-Kidney Transplant Recipient: Case Report
- Creators
- S. Guy - Drexel UniversityA. Potluri - Drexel UniversityG. Xiao - Drexel UniversityM. L. Vega - Thomas Jefferson University HospitalG. Malat - Drexel UniversityK. Ranganna - Drexel UniversityC. Cusack - Drexel UniversityA. M. Doyle - Drexel University
- Publication Details
- Transplantation proceedings, v 46(7), pp 2446-2449
- Publisher
- Elsevier
- Number of pages
- 4
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Medicine (Graduate); College of Medicine; Design; Surgery
- Web of Science ID
- WOS:000342397500066
- Scopus ID
- 2-s2.0-84908126027
- Other Identifier
- 991019168482104721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Immunology
- Surgery
- Transplantation