Journal article
Successful treatment of severe or methotrexate-resistant juvenile localized scleroderma with mycophenolate mofetil
Rheumatology (Oxford, England), v 48(11), pp 1410-1413
Nov 2009
PMID: 19713439
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Objective. To evaluate the efficacy of mycophenolate mofetil (MMF) in the treatment of severe refractory juvenile localized scleroderma (JLS). Methods. A retrospective chart review was performed in patients with JLS who had been treated with MMF after the failure of a combination of MTX and corticosteroids for at least 4 months, or whose JLS had concomitant severe extracutaneous manifestations. Outcome was assessed through clinical examination and thermography. Adverse events were recorded. Results. Ten patients (six females and four males) were enrolled in the study. JLS clinical subtypes were deep morphoea (two patients with disabling pansclerotic morphoea), generalized morphoea (three patients), linear scleroderma (five patients) affecting the limbs in two and face in three patients (en coup de sabre). The age at onset of disease was 8 (range 2–16) years, and the disease duration at the time of treatment with MMF was 18 (range 8–62) months. All MMF-treated patients experienced clinical improvement that allowed withdrawal or reduction of doses of corticosteroids and MTX. Over a follow-up of 27 (range 6–36) months, mild abdominal discomfort was reported in only one patient. Conclusions. MMF appears to be effective in arresting disease progression in severe or MTX-refractory JLS and is generally well tolerated. Further controlled studies are needed to confirm these data.
Metrics
Details
- Title
- Successful treatment of severe or methotrexate-resistant juvenile localized scleroderma with mycophenolate mofetil
- Creators
- Giorgia Martini - University of PaduaAthimalaipet V. Ramanan - Bristol Medical School (THS)Fernanda Falcini - Royal National Hospital for Rheumatic DiseasesHermann Girschick - Royal National Hospital for Rheumatic DiseasesDonald P. Goldsmith - Royal National Hospital for Rheumatic DiseasesFrancesco Zulian - Royal National Hospital for Rheumatic Diseases
- Publication Details
- Rheumatology (Oxford, England), v 48(11), pp 1410-1413
- Publisher
- Oxford University Press
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000271577700016
- Scopus ID
- 2-s2.0-73349110091
- Other Identifier
- 991019169805004721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Rheumatology