Journal article
Superficial chest wall recurrences of breast cancer: prognostic treatment factors for combined radiation therapy and hyperthermia
Radiology, v 173(2), pp 551-558
01 Nov 1989
PMID: 2477869
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Forty-nine patients with chest wall recurrences of breast carcinoma received radiation therapy and 915-MHz microwave hyperthermia for 95 lesions. Follow-up ranged from 3 to 39 months, with five patients dying before 6 months follow-up. At 1 month follow-up, 49 (52%) of 95 lesions showed complete response; 28 (29%), partial response; and 18 (19%), no change. At 6 or more months follow-up, 54 (67%) of 81 lesions demonstrated local control; 10 (12%), partial response; six (7%), no change; and 11 (14%), local-regional recurrences. Superficial blisters occurred in 24 (25%) of 95 lesions, whereas long-term complications (deep necrosis, subcutaneous burns) occurred in seven (7%) lesions. Relapse occurred in 16 (17%) lesions, seven after initial complete response and nine after partial response. Several prognostic treatment factors were identified: applied radiation dose (greater than 30 Gy, P less than .01), size of tumor (less than 6 cm diameter, P less than .001), minimum tumor temperature (greater than 41 degrees C, P less than .001), and status of disease (M0 or M1 vs M2, P less than .001). Treatment complications were correlated with maximum temperatures (greater than 45 degrees C, P less than .001). In summary the palliative treatment concept proved to be safe and effective.
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Details
- Title
- Superficial chest wall recurrences of breast cancer: prognostic treatment factors for combined radiation therapy and hyperthermia
- Creators
- H M Seegenschmiedt - University of Erlangen-NurembergU L Karlsson - University of Erlangen-NurembergR Sauer - University of Erlangen-NurembergL W Brady - Friedrich-Alexander-Universität Erlangen-NürnbergM Herbst - University of Erlangen-NurembergB E Amendola - University of Erlangen-NurembergA M Markoe - University of Erlangen-NurembergS A Fisher - University of Erlangen-NurembergB Micaily - University of Erlangen-Nuremberg
- Publication Details
- Radiology, v 173(2), pp 551-558
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Radiation Oncology (and Nuclear Medicine)
- Web of Science ID
- WOS:A1989AV60500054
- Scopus ID
- 2-s2.0-0024341951
- Other Identifier
- 991019184209104721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Radiology, Nuclear Medicine & Medical Imaging