Journal article
Suppressive antibacterial therapy with 0.75% metronidazole vaginal gel to prevent recurrent bacterial vaginosis
American journal of obstetrics and gynecology, v 194(5), pp 1283-1289
2006
PMID: 16647911
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Efficacy study of suppressive vaginal metronidazole in reducing recurrent symptomatic episodes of bacterial vaginosis.
Multicenter prospective study with initial 10-day open-label metronidazole gel in which asymptomatic responders randomly assigned to receive twice weekly metronidazole vaginal gel or placebo for 16 weeks and off therapy for 12 weeks.
Of 157 eligible women with recurrent bacterial vaginosis, 112 of 127 returning evaluable women (88.2%) responded clinically and were randomly assigned. During suppressive therapy, recurrent bacterial vaginosis occurred in 13 women (25.5%) receiving metronidazole and 26 (59.1%) receiving placebo (MITT analysis, relative risk [RR] 0.43, CI = 0.25-0.73,
P = .001). During the entire 28-week follow-up, recurrence occurred in 26 (51.0%) on treatment compared with 33 (75%) on placebo (RR 0.68, CI = 0.49-0.93,
P = .02). Probability for remaining cured was 70% for metronidazole compared with 39% on placebo, which declined to 34% and 18%, respectively, by 28 weeks follow-up. Adverse effects were uncommon; however, secondary vaginal candidiasis occurred significantly more often in metronidazole-treated women (
P = .02).
Suppressive therapy with twice-weekly metronidazole gel achieves a significant reduction in the recurrence rate of bacterial vaginosis; however, secondary vaginal candidiasis is common.
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Details
- Title
- Suppressive antibacterial therapy with 0.75% metronidazole vaginal gel to prevent recurrent bacterial vaginosis
- Creators
- Jack D. Sobel - Wayne State UniversityDaron Ferris - Augusta UniversityJane Schwebke - University of Alabama at BirminghamPaul Nyirjesy - Drexel UniversityHarold C. Wiesenfeld - University of PittsburghJeffrey Peipert - Brown UniversityDavid Soper - Medical University of South CarolinaSuzanne E. Ohmit - Wayne State UniversitySharon L. Hillier - University of Pittsburgh
- Publication Details
- American journal of obstetrics and gynecology, v 194(5), pp 1283-1289
- Publisher
- Mosby, Inc
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000237331900015
- Scopus ID
- 2-s2.0-33646118730
- Other Identifier
- 991019350594504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Obstetrics & Gynecology