Journal article
Supramammillary neurons projecting to the septum regulate dopamine and motivation for environmental interaction in mice
Nature communications, v 12(1), pp 2811-2811
14 May 2021
PMID: 33990558
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The supramammillary region (SuM) is a posterior hypothalamic structure, known to regulate hippocampal theta oscillations and arousal. However, recent studies reported that the stimulation of SuM neurons with neuroactive chemicals, including substances of abuse, is reinforcing. We conducted experiments to elucidate how SuM neurons mediate such effects. Using optogenetics, we found that the excitation of SuM glutamatergic (GLU) neurons was reinforcing in mice; this effect was relayed by their projections to septal GLU neurons. SuM neurons were active during exploration and approach behavior and diminished activity during sucrose consumption. Consistently, inhibition of SuM neurons disrupted approach responses, but not sucrose consumption. Such functions are similar to those of mesolimbic dopamine neurons. Indeed, the stimulation of SuM-to-septum GLU neurons and septum-to-ventral tegmental area (VTA) GLU neurons activated mesolimbic dopamine neurons. We propose that the supramammillo-septo-VTA pathway regulates arousal that reinforces and energizes behavioral interaction with the environment.
The supramammillary region (SuM) regulates arousal that reinforces and energizes behavioral interaction with the environment. Here the authors investigate how SuM neurons interact with medial septal neurons and ventral tegmental dopamine neurons to regulate motivation for environmental interaction.
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Details
- Title
- Supramammillary neurons projecting to the septum regulate dopamine and motivation for environmental interaction in mice
- Creators
- Andrew J. Kesner - National Institute on Drug AbuseRick Shin - National Institute on Drug AbuseColeman B. Calva - National Institute on Drug AbuseReuben F. Don - National Institute on Drug AbuseSue Junn - National Institute on Drug AbuseChristian T. Potter - National Institute on Drug AbuseLeslie A. Ramsey - Baltimore, MD USAAhmed F. Abou-Elnaga - National Institute on Drug AbuseChristopher G. Cover - National Institute on Drug AbuseDong V. Wang - Baltimore, MD USAHanbing Lu - National Institute on Drug AbuseYihong Yang - National Institute on Drug AbuseSatoshi Ikemoto - National Institute on Drug Abuse
- Publication Details
- Nature communications, v 12(1), pp 2811-2811
- Publisher
- Nature Publishing Group UK
- Grant note
- DA000575-10 / ;
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000658731700008
- Scopus ID
- 2-s2.0-85105944199
- Other Identifier
- 991020099991504721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Neurosciences