Journal article
Supramolecular Guest-Host Interactions for the Preparation of Biomedical Materials
Bioconjugate chemistry, v 26(12), pp 2279-2289
01 Dec 2015
PMID: 26439898
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Supramolecular chemistry has emerged as an important technique for the formation of biomaterials, including nano- and microparticles and hydrogels. One specific class of supramolecular chemistry is the direct association of guest host pairs, which involves host macrocycles such as cydodextrins and cucurbit[n]urils and a wide range of guest molecules, where association is typically driven by molecule size and hydrophobicity. These systems are of particular interest in the biomedical field due to their dynamic nature, chemical diversity, relative ease of synthesis, and ability to interact with biological or synthetic molecules. In this review, we discuss aspects of polymeric material assembly mediated by guest host interactions, including the fundamentals of assembly into functional biomedical materials. Additionally, applications of biomaterials that utilize guest host interactions are discussed with a focus on injectable material formulations, the sequestration and delivery of encapsulated cargo (i.e., drugs, biomolecules), and the investigation of cell material interactions (i.e., adhesion, differentiation, and delivery). While methodologies for guest host mediated assembly and biological interaction have rapidly evolved in recent years, they remain far from realizing their full potential in the biomaterials field.
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Details
- Title
- Supramolecular Guest-Host Interactions for the Preparation of Biomedical Materials
- Creators
- Christopher B. Rodell - University of PennsylvaniaJoshua E. Mealy - University of PennsylvaniaJason A. Burdick - University of Pennsylvania
- Publication Details
- Bioconjugate chemistry, v 26(12), pp 2279-2289
- Publisher
- American Chemical Society; Washington, DC
- Number of pages
- 11
- Grant note
- National Science Foundation; National Science Foundation (NSF) American Heart Association
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000366877400001
- Scopus ID
- 2-s2.0-84950143177
- Other Identifier
- 991019176642404721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Biochemical Research Methods
- Biochemistry & Molecular Biology
- Chemistry, Multidisciplinary
- Chemistry, Organic