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Journal article
Surface Curvature as a Classifier of Abdominal Aortic Aneurysms: A Comparative Analysis
Annals of biomedical engineering, v 41(3), pp 562-576
01 Mar 2013
PMID: 23180028
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
An abdominal aortic aneurysm (AAA) carries one of the highest mortality rates among vascular diseases when it ruptures. To predict the role of surface curvature in rupture risk assessment, a discriminatory analysis of aneurysm geometry characterization was conducted. Data was obtained from 205 patient-specific computed tomography image sets corresponding to three AAA population subgroups: patients under surveillance, those that underwent elective repair of the aneurysm, and those with an emergent repair. Each AAA was reconstructed and their surface curvatures estimated using the biquintic Hermite finite element method. Local surface curvatures were processed into ten global curvature indices. Statistical analysis of the data revealed that the L2-norm of the Gaussian and Mean surface curvatures can be utilized as classifiers of the three AAA population subgroups. The application of statistical machine learning on the curvature features yielded 85.5% accuracy in classifying electively and emergent repaired AAAs, compared to a 68.9% accuracy obtained by using maximum aneurysm diameter alone. Such combination of non-invasive geometric quantification and statistical machine learning methods can be used in a clinical setting to assess the risk of rupture of aneurysms during regular patient follow-ups.
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Details
- Title
- Surface Curvature as a Classifier of Abdominal Aortic Aneurysms: A Comparative Analysis
- Creators
- Kibaek Lee - Carnegie Mellon UniversityJunjun Zhu - Carnegie Mellon UniversityJudy Shum - Carnegie Mellon UniversityYongjie Zhang - Carnegie Mellon UniversitySatish C. Muluk - Allegheny Health NetworkAnkur Chandra - University of RochesterMark K. Eskandari - Northwestern UniversityEnder A. Finol - The University of Texas at San Antonio
- Publication Details
- Annals of biomedical engineering, v 41(3), pp 562-576
- Publisher
- Springer Nature
- Number of pages
- 15
- Grant note
- R21EB007651; R21EB008804; R15HL087268 / NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R21EB007651 / NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Biomedical Imaging & Bioengineering (NIBIB) Vlahakis Graduate Fellowship program R15HL087268 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI) Korean Government Scholarship Program for Study Overseas
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Cardiothoracic Surgery
- Web of Science ID
- WOS:000316295800010
- Scopus ID
- 2-s2.0-84876168686
- Other Identifier
- 991021944490304721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Engineering, Biomedical