Journal article
Surface modification of SU-8 for enhanced cell attachment and proliferation within microfluidic chips
Journal of biomedical materials research. Part B, Applied biomaterials, v 103(2), pp 473-484
01 Feb 2015
PMID: 24919697
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Advances in micro-electro-mechanical systems (MEMS) have led to an increased fabrication of micro-channels. Microfabrication techniques are utilized to develop microfluidic channels for continuous nutrition supply to cells inside a micro-environment. The ability of cells to build tissues and maintain tissue-specific functions depends on the interaction between cells and the extracellular matrix (ECM). SU-8 is a popular photosensitive epoxy-based polymer in MEMS. The patterning of bare SU-8 alone does not provide the appropriate ECM necessary to develop microsystems for biological applications. Manipulating the chemical composition of SU-8 will enhance the biological compatibility, giving the fabricated constructs the appropriate ECM needed to promote a functional tissue array. This article investigates three frequently used surface treatment techniques: (1) plasma treatment, (2) chemical reaction, and (3) deposition treatment to determine which surface treatment is the most beneficial for enhancing the biological properties of SU-8. The investigations presented in this article demonstrated that the plasma, gelatin, and sulfuric acid treatments have a potential to enhance SU-8's surface for biological application. Of course each treatment has their advantages and disadvantages (application dependent). Cell proliferation was studied with the use of the dye Almar Blue, and a micro-plate reader. After 14 days, cell proliferation to plasma treated surfaces was statistically significantly enhanced (p<0.00001), compared to untreated surfaces. The plasma treated surface is suggested to be the better of the three treatments for biological enhancement followed by gelatin and sulfuric acid treatments, respectively. (c) 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 473-484, 2015.
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Details
- Title
- Surface modification of SU-8 for enhanced cell attachment and proliferation within microfluidic chips
- Creators
- Qudus Hamid - Drexel UniversityChengyang Wang - Drexel UniversityJessica Snyder - Drexel UniversityWei Sun - Drexel University
- Publication Details
- Journal of biomedical materials research. Part B, Applied biomaterials, v 103(2), pp 473-484
- Publisher
- Wiley
- Number of pages
- 12
- Grant note
- 1209517 / National Science Foundation; National Science Foundation (NSF)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Mechanical Engineering and Mechanics
- Web of Science ID
- WOS:000348419700026
- Scopus ID
- 2-s2.0-84920841048
- Other Identifier
- 991019167441904721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials