Journal article
Surfactant-stabilized contrast agent on the nanoscale for diagnostic ultrasound imaging
Ultrasound in medicine & biology, v 32(1), pp 83-93
2006
PMID: 16364800
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Ultrasound contrast agents (CA) are generally micron-sized stabilized gas bubbles, injected IV. However, to penetrate beyond the vasculature and accumulate in targets such as tumors, CA must be an order of magnitude smaller. We describe a method of achieving nanometer-sized, surfactant-stabilized CA by differential centrifugation. High
g force was shown to destroy bubble integrity. Optimal conditions (300 rpm for 3 min) produced an agent with a mean diameter of 450 nm, which gave 25.5 dB enhancement
in vitro at a dose of 10 μL/mL, with a 13 min half-life.
In vivo, the CA produced excellent power Doppler and grey-scale pulse inversion harmonic images at low acoustic power when administered.
In vivo dose-response curves obtained in three rabbits showed enhancement between 20 and 25 dB for dosages above 0.025 mL/kg. These results encourage further investigation of the possible diagnostic and therapeutic benefits of using nanoparticles as CA, including passive targeting and accumulation in tumors. (E-mail:
wheatley@coe.drexel.edu)
Metrics
Details
- Title
- Surfactant-stabilized contrast agent on the nanoscale for diagnostic ultrasound imaging
- Creators
- Margaret A Wheatley - School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, USAFlemming Forsberg - Department of Radiology, Thomas Jefferson University Hospital, Philadelphia, PA, USANeal Dube - School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, USAMihir Patel - School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, USABrian E Oeffinger - School of Biomedical Engineering, Science and Health Systems, Drexel University, Philadelphia, PA, USA
- Publication Details
- Ultrasound in medicine & biology, v 32(1), pp 83-93
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- School of Biomedical Engineering, Science, and Health Systems
- Web of Science ID
- WOS:000234443200010
- Scopus ID
- 2-s2.0-29144460186
- Other Identifier
- 991014877824804721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Acoustics
- Radiology, Nuclear Medicine & Medical Imaging