Journal article
Surgical Resection Should Be Considered for Stage I and II Small Cell Carcinoma of the Lung
The Annals of thoracic surgery, v 94(3), pp 889-894
01 Sep 2012
PMID: 22429675
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Background. Small cell lung carcinoma (SCLC) is rarely treated with resection, either alone or combined with other modalities. This study evaluated the role of surgical resection in the treatment of stage I and II SCLC.
Methods. We queried the Surveillance, Epidemiology, and End Results (SEER) database for patients from 1988 to 2007 with SCLC. Survival was determined by Kaplan-Meier analysis and compared using the log-rank test. A Cox proportional hazard model identified relevant survival variables.
Results. We identified 3,566 patients with stage I or II SCLC. Lung resection was performed in 895 (25.1%), wedge resection in 251 (28.0%), lobectomy or pneumonectomy in 637 (71.2%), and lung resection not otherwise specified in 7 (0.78%). Median survival was 34.0 months (95% confidence interval [CI], 29.0 to 39.0 months) vs 16.0 months (95% CI, 15.3 to 16.7; p < 0.001) in nonsurgical patients. Median survival after lobectomy or pneumonectomy was 39.0 months (95% CI, 30.7 to 40.3) and significantly longer than after wedge resection (28.0 months; 95% CI, 23.2 to 32.8; p = 0.001). However, survival after wedge resection was still significantly longer than survival in nonsurgical patients (p < 0.001). Sex (p = 0.013), age, stage at diagnosis, radiotherapy, and operation (all p < 0.001) significantly affected survival. In the surgical patients, sex (p = 0.001), age (p < 0.001), final stage (p < 0.001), and type of resection (p = 0.01) were important determinants of survival.
Conclusions. Surgical resection as a component of treatment for stage I or II SCLC is associated with significantly improved survival and should be considered in the management of early-stage SCLC. (Ann Thorac Surg 2012;94:889-94) (C) 2012 by The Society of Thoracic Surgeons
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Details
- Title
- Surgical Resection Should Be Considered for Stage I and II Small Cell Carcinoma of the Lung
- Creators
- Benny Weksler - University of PittsburghKatie S. Nason - University of Pittsburgh Medical CenterManisha Shende - University of Pittsburgh Medical CenterRodney J. Landreneau - University of Pittsburgh Medical CenterArjun Pennathur - University of Pittsburgh Medical Center
- Publication Details
- The Annals of thoracic surgery, v 94(3), pp 889-894
- Publisher
- Elsevier
- Number of pages
- 7
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Surgery
- Web of Science ID
- WOS:000308138900038
- Scopus ID
- 2-s2.0-84864872321
- Other Identifier
- 991021960798004721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Cardiac & Cardiovascular Systems
- Respiratory System
- Surgery