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Survival of the ganglion cell population in the rabbit retina following neonatal visual cortex ablation
Journal article   Peer reviewed

Survival of the ganglion cell population in the rabbit retina following neonatal visual cortex ablation

Mary Wilkes, Gloria Zingaro and E.Hazel Murphy
Brain research. Developmental brain research, v 21(2), pp 293-297
1985
PMID: 4041910

Abstract

development retina transneuronal degeneration
Unilateral visual cortex ablations in neonatal rabbits produced no detectable loss of ganglion cells in the contralateral retina following a survival period of 3, 4 or 8 months. Analysis of neuron size distributions and neuron densities from whole-mounted retinas indicate that transneuronal retrograde degeneration does not occur in the rabbit following neonatal visual cortex removal. The results support the hypothesis that axon collaterals play a role in retinal ganglion cell survival in neonatally operated animals. The paradoxical relationship between functional sparing and ganglion cell survival is discussed.

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Developmental Biology
Neurosciences
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