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Journal article
Susceptibility of the conventional criteria for mild cognitive impairment to false-positive diagnostic errors
Alzheimer's & dementia, v 11(4), pp 415-424
Apr 2015
PMID: 24857234
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
We assessed whether mild cognitive impairment (MCI) subtypes could be empirically derived within the Alzheimer's Disease Neuroimaging Initiative (ADNI) MCI cohort and examined associated biomarkers and clinical outcomes.
Cluster analysis was performed on neuropsychological data from 825 MCI ADNI participants.
Four subtypes emerged: (1) dysnomic (n = 153), (2) dysexecutive (n = 102), (3) amnestic (n = 288), and (4) cluster-derived normal (n = 282) who performed within normal limits on cognitive testing. The cluster-derived normal group had significantly fewer APOE ε4 carriers and fewer who progressed to dementia compared with the other subtypes; they also evidenced cerebrospinal fluid Alzheimer's disease biomarker profiles that did not differ from the normative reference group.
Identification of empirically derived MCI subtypes demonstrates heterogeneity in MCI cognitive profiles that is not captured by conventional criteria. The large cluster-derived normal group suggests that conventional diagnostic criteria are susceptible to false-positive errors, with the result that prior MCI studies may be diluting important biomarker relationships.
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Details
- Title
- Susceptibility of the conventional criteria for mild cognitive impairment to false-positive diagnostic errors
- Creators
- Emily C. Edmonds - University of California San DiegoLisa Delano-Wood - University of California - San Diego School of MedicineLindsay R. Clark - San Diego State UniversityAmy J. Jak - VA San Diego Healthcare SystemDaniel A. Nation - University of Southern CaliforniaCarrie R. McDonald - University of California San DiegoDavid J. Libon - Drexel UniversityRhoda Au - Framingham Heart StudyDouglas Galasko - University of California San DiegoDavid P. Salmon - University of California San DiegoMark W. Bondi - VA San Diego Healthcare SystemAlzheimer's Disease Neuroimaging Initiative
- Publication Details
- Alzheimer's & dementia, v 11(4), pp 415-424
- Publisher
- Elsevier
- Number of pages
- 10
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000353431800004
- Scopus ID
- 2-s2.0-84927173992
- Other Identifier
- 991021901313904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology