Files and links (1)
Accepted (AM)Open Access (License Unspecified), Open
Journal article
Susceptibility to traumatic stress sensitizes the dopaminergic response to cocaine and increases motivation for cocaine
Neuropharmacology, v 125, pp 295-307
01 Oct 2017
PMID: 28778834
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Patients with post-traumatic stress disorder have a heightened vulnerability to developing substance use disorders; however, the biological underpinnings of this vulnerability remain unresolved. We used the predator odor stress model of post-traumatic stress disorder with segregation of subjects as susceptible or resilient based on elevated plus maze behavior and context avoidance. We then determined behavioral and neurochemical differences across susceptible, resilient, and control populations using a panel of behavioral and neurochemical assays. Susceptible subjects showed a significant increase in the motoric and dopaminergic effects of cocaine, and this corresponded with heightened motivation to selfadminister cocaine. Resilient subjects did not show differences in the motoric effects of cocaine, in dopamine signaling in vivo, or in any measure of cocaine self-administration. Nonetheless, we found that these animals displayed elevations in both the dopamine release-promoting effects of cocaine and dopamine autoreceptor sensitivity ex vivo. Our results suggest that the experience of traumatic stress may produce alterations in dopamine systems that drive elevations in cocaine self-administration behavior in susceptible subjects, but may also produce both active and passive forms of resilience that function to prevent gross changes in cocaine's reinforcing efficacy in resilient subjects. (C) 2017 Elsevier Ltd. All rights reserved.
Metrics
Details
- Title
- Susceptibility to traumatic stress sensitizes the dopaminergic response to cocaine and increases motivation for cocaine
- Creators
- Zachary D. Brodnik - Drexel UniversityEmily M. Black - Drexel UniversityMeagan J. Clark - Drexel UniversityKristen N. Kornsey - Drexel UniversityNathaniel W. Snyder - Drexel UniversityRodrigo A. Espana - Drexel University
- Publication Details
- Neuropharmacology, v 125, pp 295-307
- Publisher
- Elsevier
- Number of pages
- 13
- Grant note
- R21HD087866 / EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) R01DA031900 / NATIONAL INSTITUTE ON DRUG ABUSE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Drug Abuse (NIDA); European Commission Drexel University Dean's Fellowship for Excellence in Collaborative or Themed Research K22ES026235 / NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy; A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000411775700026
- Scopus ID
- 2-s2.0-85026824980
- Other Identifier
- 991019167891704721
UN Sustainable Development Goals (SDGs)
This publication has contributed to the advancement of the following goals:
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Neurosciences
- Pharmacology & Pharmacy