Journal article
Sustainability inspired fabrication of next generation neurostimulation and cardiac rhythm management electrodes via reactive hierarchical surface restructuring
Microsystems & nanoengineering, v 10(1), pp 125-16
09 Sep 2024
PMID: 39251609
Abstract
Over the last two decades, platinum group metals (PGMs) and their alloys have dominated as the materials of choice for electrodes in long-term implantable neurostimulation and cardiac rhythm management devices due to their superior conductivity, mechanical and chemical stability, biocompatibility, corrosion resistance, radiopacity, and electrochemical performance. Despite these benefits, PGM manufacturing processes are extremely costly, complex, and challenging with potential health hazards. Additionally, the volatility in PGM prices and their high supply risk, combined with their scarce concentration of approximately 0.01 ppm in the earth's upper crust and limited mining geographical areas, underscores their classification as critical raw materials, thus, their effective recovery or substitution worldwide is of paramount importance. Since postmortem recovery from deceased patients and/or refining of PGMs that are used in the manufacturing of the electrodes and microelectrode arrays is extremely rare, challenging, and highly costly, therefore, substitution of PGM-based electrodes with other biocompatible materials that can yield electrochemical performance values equal or greater than PGMs is the only viable and sustainable solution to reduce and ultimately substitute the use of PGMs in long-term implantable neurostimulation and cardiac rhythm management devices. In this article, we demonstrate for the first time how the novel technique of "reactive hierarchical surface restructuring" can be utilized on titanium-that is widely used in many non-stimulation medical device and implant applications-to manufacture biocompatible, low-cost, sustainable, and high-performing neurostimulation and cardiac rhythm management electrodes. We have shown how the surface of titanium electrodes with extremely poor electrochemical performance undergoes compositional and topographical transformations that result in electrodes with outstanding electrochemical performance.
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Details
- Title
- Sustainability inspired fabrication of next generation neurostimulation and cardiac rhythm management electrodes via reactive hierarchical surface restructuring
- Creators
- Shahram Amini - Pulse BiosciencesHongbin Choi - University of ConnecticutWesley Seche - Pulse BiosciencesAlexander Blagojevic - University of ConnecticutNicholas May - University of ConnecticutBenjamin M. Lefler - Drexel UniversitySkyler L. Davis - Colorado School of MinesSahar Elyahoodayan - University of Southern CaliforniaPouya Tavousi - University of ConnecticutSteven J. May - Drexel UniversityGregory A. Caputo - Rowan UniversityTerry C. Lowe - Colorado School of MinesJeffrey Hettinger - Rowan UniversitySina Shahbazmohamadi - University of Connecticut
- Publication Details
- Microsystems & nanoengineering, v 10(1), pp 125-16
- Publisher
- Springer Nature
- Number of pages
- 16
- Grant note
- NNCI-2025608 / National Science Foundation; National Science Foundation (NSF)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering
- Web of Science ID
- WOS:001308562900001
- Scopus ID
- 2-s2.0-85203323903
- Other Identifier
- 991021934114404721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Instruments & Instrumentation
- Nanoscience & Nanotechnology