Journal article
Sweat mechanisms and dysfunctions in atopic dermatitis
Journal of dermatological science, v 89(2), pp 105-111
Feb 2018
PMID: 29169766
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
•Eccrine sweat contributes to skin barrier integrity, thermoregulation, and immune defense.•AD patients have sweat-associated dysfunctions, including altered sweat composition, sweat allergy, and abnormal sweat pattern and response.•Sweat management may represent a potential therapeutic approach in AD.
Skin barrier dysfunction is inherent to atopic dermatitis (AD), causing dryness, irritation, and increased permeability to irritants, allergens and pathogens. Eccrine sweat functions as part of the skin’s protective barrier. Variations in sweat responses have been observed in patients with AD, and altered sweat composition and dynamics are under-recognized as important factors in the disease cycle. This review discusses the role that sweat plays in the pathogenesis of AD, examines evidence on abnormal sweat composition, secretion, and neuro-immune responses to sweat in atopic skin, and highlights the value of sweat management.
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Details
- Title
- Sweat mechanisms and dysfunctions in atopic dermatitis
- Creators
- Aleksi J. Hendricks - University of ArizonaAlexandra R. Vaughn - Drexel UniversityAshley K. Clark - University of California, DavisGil Yosipovitch - University of MiamiVivian Y. Shi - University of Arizona
- Publication Details
- Journal of dermatological science, v 89(2), pp 105-111
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Web of Science ID
- WOS:000425580500001
- Scopus ID
- 2-s2.0-85034607228
- Other Identifier
- 991019357775904721
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- Collaboration types
- Domestic collaboration
- Web of Science research areas
- Dermatology