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Accepted (AM)Open Access (License Unspecified), Open
Journal article
Synaptic vesicle release regulates myelin sheath number of individual oligodendrocytes in vivo
Nature neuroscience, v 18(5), pp 628-630
01 May 2015
PMID: 25849985
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The myelination of axons by oligodendrocytes markedly affects CNS function, but how this is regulated by neuronal activity in vivo is not known. We found that blocking synaptic vesicle release impaired CNS myelination by reducing the number of myelin sheaths made by individual oligodendrocytes during their short period of formation. We also found that stimulating neuronal activity increased myelin sheath formation by individual oligodendrocytes. These data indicate that neuronal activity regulates the myelinating capacity of single oligodendrocytes.
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Details
- Title
- Synaptic vesicle release regulates myelin sheath number of individual oligodendrocytes in vivo
- Creators
- Sigrid Mensch - University of EdinburghMarion Baraban - University of EdinburghRafael Almeida - University of EdinburghTim Czopka - University of EdinburghJessica Ausborn - Karolinska InstitutetAbdeljabbar El Manira - Karolinska InstitutetDavid A. Lyons - University of Edinburgh
- Publication Details
- Nature neuroscience, v 18(5), pp 628-630
- Publisher
- Springer Nature
- Number of pages
- 5
- Grant note
- BB/F023243/1 / BBSRC; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC) Wellcome Trust Senior Research Fellowship; Wellcome Trust MR/K015710/1 / Medical Research Council; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); European Commission Lister Research Prize BBSRC David Phillips Fellowship; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC) BB/F023243/1 / Biotechnology and Biological Sciences Research Council; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC) 102836/Z/13/Z / Wellcome Trust; European Commission MR/K015710/1 / MRC; UK Research & Innovation (UKRI); Medical Research Council UK (MRC)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Neurobiology and Anatomy
- Web of Science ID
- WOS:000353636900008
- Scopus ID
- 2-s2.0-84928699119
- Other Identifier
- 991020655544704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Neurosciences