Journal article
Synchronous Primary Central Nervous System and Pulmonary Lymphoma in a 7-Year-Old Female with Unspecified T-Cell Immunodeficiency
Pediatric neurosurgery, v 53(5)
2018
PMID: 30110687
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Primary central nervous system lymphoma (PCNSL) is rare in children with immunocompromise as an important risk factor. A 7-year-old girl with unspecified T-cell immunodeficiency presented with left-sided weakness and was found to have a right-sided frontal lobe mass on imaging. The mass was resected; histopathology and molecular studies evidenced diffuse large B-cell lymphoma. Prior chest imaging had revealed left upper lobe mass, and repeat chest imaging revealed multiple pulmonary nodules, initially concerning for metastasis. Video-assisted thoracoscopic surgical wedge resection of the lung mass was performed; the molecular profile was distinct from the PCNSL, suggesting synchronous de novo lymphomagenesis of brain and pulmonary primaries.
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Details
- Title
- Synchronous Primary Central Nervous System and Pulmonary Lymphoma in a 7-Year-Old Female with Unspecified T-Cell Immunodeficiency
- Creators
- Michael G Z Ghali - Methodist HospitalAyman Samkari - St. Christopher's Hospital for ChildrenJ Steve Hou - Drexel UniversityManjula Balasubramanian - St. Christopher's Hospital for ChildrenSherri Besmer - St. Christopher's Hospital for ChildrenMatthew Keisling - Akron Children's HospitalPrithvi Narayan - St. Christopher's Hospital for Children
- Publication Details
- Pediatric neurosurgery, v 53(5)
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pediatrics
- Web of Science ID
- WOS:000452899500004
- Scopus ID
- 2-s2.0-85052626953
- Other Identifier
- 991019168811404721
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- Collaboration types
- Industry collaboration
- Domestic collaboration
- Web of Science research areas
- Clinical Neurology
- Pediatrics
- Surgery