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Synergistic Bactericidal Activity of Rat Serum with Vancomycin against Enterococci
Journal article   Peer reviewed

Synergistic Bactericidal Activity of Rat Serum with Vancomycin against Enterococci

Marla J. Gold, Julieta Calmon, Michael Wendeler, Matthew E. Levison and Caroline C. Johnson
The Journal of infectious diseases, v 163(6), pp 1358-1361
Jun 1991
DOI: https://doi.org/10.1093/infdis/163.6.1358
PMID: 1903800
Featured in Collection :   UN Sustainable Development Goals @ Drexel

Abstract

Animal models of infectious diseases may not predict clinical efficacy when species-related factors come into play. Recently, unexpected bactericidal activity of vancomycin alone against enterococci was observed in a rat model of endocarditis. A factor or factors in rat serum, but not rabbit or human serum, enhanced in vitro killing by vancomycinin four of five clinical isolates of enterococci. Bactericidal activity was maintained on dilution of rat serum to 5.0% and after exposure of serum to 56°C for 30 min. Activity was lost by heating at 60°C for 2 h, ultrafiltration, or absorption with bentonite or heat-killed bacteria. Rat serum appears to contain a factor or factors that contribute bactericidal activity to vancomycin,a drug normally bacteriostatic for these enterococci. The mechanism by which this factor enhances killing of enterococci by vancomycin is unknown.

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15 citations in Web of Science
11 citations in Scopus

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Web of Science research areas
Immunology
Infectious Diseases
Microbiology
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