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Syntactic comprehension deficits are associated with MRI white matter alterations in dementia
Journal article   Open access

Syntactic comprehension deficits are associated with MRI white matter alterations in dementia

Tania Giovannetti, Mary W. Hopkins, Jaclyn Crawford, Brianne Magouirk Bettcher, Kara S. Schmidt and David J. Libon
Journal of the International Neuropsychological Society, v 14(4), pp 542-551
01 Jul 2008
DOI: https://doi.org/10.1017/S1355617708080715
PMID: 18577283
Featured in Collection :   UN Sustainable Development Goals @ Drexel
url
https://doi.org/10.1017/s1355617708080715View
Published, Version of Record (VoR)Maybe Open Access (Publisher Bronze),  Open
url
https://doi.org/10.1017/S1355617708080715View
Published, Version of Record (VoR) Open

Abstract

Clinical Neurology Life Sciences & Biomedicine Neurosciences Neurosciences & Neurology Psychiatry Psychology Science & Technology Social Sciences
Comprehension difficulties associated with periventricular and deep white matter alterations (WMA) in mild dementia were investigated using portions of the Boston Diagnostic Aphasia Examination (BDAE) Complex Ideation subtest and Syntax subtests. Mild dementia participants were grouped according to the extent of their WMA as observed on magnetic resonance imaging (mild WMA it = 45 vs. moderate to severe WMA n = 52). Correlation and regression analyses also were performed to examine the link between WMA and comprehension abilities, as well as the link between comprehension abilities and neuropsychological measures of executive functioning, language, episodic mernory, and overall dementia severity. Results showed that the WMA groups differed on the BDAE-Syntax subtests, with the severe WMA group demonstrating more impairment. Correlation and regression analyses including the entire sample also demonstrated that the extent of WMA was significantly linked to Syntax test scores but not Complex Ideation scores. Regression analyses including neuropsychological measures showed that the BDAE-Complex Ideation score was marginally predicted by only overall dementia severity, whereas the BDAE-Syntax scores were significantly predicted by independent measures of working memory/executive functioning. In conclusion, greater subcortical WMA and executive deficits are associated with greater difficulties in syntactic comprehension in individuals with mild dementia.

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7 citations in Scopus

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Collaboration types
Domestic collaboration
Web of Science research areas
Clinical Neurology
Neurosciences
Psychiatry
Psychology
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