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Syntheses and Tissue Distribution of 99mTc-Sulfonylureas
Journal article   Peer reviewed

Syntheses and Tissue Distribution of 99mTc-Sulfonylureas

Ned D. Heindel, Victor R. Risch, H. Donald Burns, Takashi Honda, Luther W. Brady and Marlynne Micalizzi
Journal of pharmaceutical sciences, v 64(4), pp 687-689
Apr 1975

Abstract

Hypoglycemic agents—synthesis and screening of sulfonylureas, tissue distribution of 99mTc‐chelates Pancreatic imaging agents, potential—synthesis and tissue distribution of 99mTc‐sulfonylureas Radiolabeled sulfonylureas—tissue distribution of 99mTc‐chelates, potential pancreatic imaging agents Sulfonylureas—synthesized and screened as hypoglycemics, tissue distribution of 99mTc‐chelates, potential pancreatic imaging agents
Four new tolbutamide analogs were prepared and evaluated as hypoglycemics. Hypoglycemic action was observed in two members of the class, and 99mTc‐chelates were tested as potential radiopharmaceutical imaging agents.

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