Journal article
Synthesis and SAR of pyridazinone-substituted phenylalanine amide alpha(4) integrin antagonists
Bioorganic & medicinal chemistry letters, v 18(4), pp 1331-1335
15 Feb 2008
PMID: 18226905
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Structural modi. cation and cellular adhesion inhibition activities of pyridazinone-substituted phenylalanine amide alpha(4) integrin antagonists are described. Functionality requirements for the arylamide moiety and the carboxylic acid group were demonstrated. The study also revealed novel structure - activity relationships (SAR) for arylated pyridazinones. A correlation between bioavailability and permeability was also explored. A selected compound showed effectiveness in a mouse leukocytosis study. (c) 2008 Elsevier Ltd. All rights reserved.
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Details
- Title
- Synthesis and SAR of pyridazinone-substituted phenylalanine amide alpha(4) integrin antagonists
- Creators
- Yong Gong - Johnson & Johnson (United States)J. Kent Barbay - Johnson & Johnson (United States)Edward S. Kimball - Johnson & Johnson (United States)Rosemary J. Santulli - Johnson & Johnson (United States)M. Carolyn Fisher - Johnson & Johnson (United States)Alexey B. Dyatkin - Johnson & Johnson (United States)Tamara A. Miskowski - Johnson & Johnson (United States)Pamela J. Hornby - Johnson & Johnson (United States)Wei He - Johnson & Johnson (United States)
- Publication Details
- Bioorganic & medicinal chemistry letters, v 18(4), pp 1331-1335
- Publisher
- Elsevier
- Number of pages
- 5
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000254180000015
- Scopus ID
- 2-s2.0-39049121296
- Other Identifier
- 991021931913804721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Chemistry, Medicinal
- Chemistry, Organic