Journal article
Synthesis and biological evaluation of fentanyl acrylic derivatives
RSC advances, v 7(32), pp 20015-20019
01 Jan 2017
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
The synthesis of novel fentanyl acrylate derivatives
via
bromo-fentanyl using Heck coupling is described. The synthesis is concise and represents an efficient and useful method for functionalizing fentanyl for medicinal chemistry investigations. The agonistic and analgesic activities are evaluated by Mu opioid receptor activation and hot plate assays in mice.
Metrics
Details
- Title
- Synthesis and biological evaluation of fentanyl acrylic derivatives
- Creators
- Shaohua Li - Allegheny General HospitalDevora Cohen-Karni - Allegheny General HospitalMarina Kovaliov - Allegheny General HospitalNestor Tomycz - Allegheny General HospitalBoyle Cheng - Allegheny General HospitalDonald Whiting - Allegheny Health NetworkSaadyah Averick - Allegheny General Hospital
- Publication Details
- RSC advances, v 7(32), pp 20015-20019
- Publisher
- Royal Society of Chemistry
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- SOM Dean - Research Administration; Surgery; Neurosurgery
- Web of Science ID
- WOS:000399242100068
- Scopus ID
- 2-s2.0-85017136142
- Other Identifier
- 991021463317704721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Chemistry, Multidisciplinary