Journal article
Synthesis and characterization of 5,6,7,8-tetrahydroquinoline C5a receptor antagonists
Bioorganic & medicinal chemistry letters, v 18(8), pp 2544-2548
15 Apr 2008
PMID: 18378452
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Synthesis and structure–activity relationships of a series of substituted 5,6,7,8-tetrahydroquinoline C5a receptor antagonists are reported.
A novel series of substituted 2-aryl-5-amino-5,6,7,8-tetrahydroquinoline C5a receptor antagonists is reported. Synthetic routes were developed that allow the substituents on the tetrahydroquinoline core to be efficiently varied, facilitating determination of structure–activity relationships. Members of the series display high binding affinity for the C5a receptor and are potent functional antagonists.
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Details
- Title
- Synthesis and characterization of 5,6,7,8-tetrahydroquinoline C5a receptor antagonists
- Creators
- J. Kent Barbay - Johnson & Johnson (United States)Yong Gong - Johnson & Johnson (United States)Mieke Buntinx - Drug Discovery, Johnson & Johnson PRD, RED EU, Turnhoutseweg 30, B-2340, Beerse, BelgiumJian Li - Johnson & Johnson (United States)Concha Claes - Drug Discovery, Johnson & Johnson PRD, RED EU, Turnhoutseweg 30, B-2340, Beerse, BelgiumPamela J. Hornby - Johnson & Johnson (United States)Guy Van Lommen - Drug Discovery, Johnson & Johnson PRD, RED EU, Turnhoutseweg 30, B-2340, Beerse, BelgiumJean Van Wauwe - Drug Discovery, Johnson & Johnson PRD, RED EU, Turnhoutseweg 30, B-2340, Beerse, BelgiumWei He - Johnson & Johnson (United States)
- Publication Details
- Bioorganic & medicinal chemistry letters, v 18(8), pp 2544-2548
- Publisher
- Elsevier
- Number of pages
- 5
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Pharmacology and Physiology
- Web of Science ID
- WOS:000255246400005
- Scopus ID
- 2-s2.0-41949133045
- Other Identifier
- 991021931780604721
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- Collaboration types
- International collaboration
- Web of Science research areas
- Chemistry, Medicinal
- Chemistry, Organic