Journal article
Synthesis and characterization of electroactive and biodegradable ABA block copolymer of polylactide and aniline pentamer
Biomaterials, v 28(10), pp 1741-1751
2007
PMID: 17218007
Abstract
A triblock copolymer PLA-
b-AP-
b-PLA (PAP) of polylactide (PLA) and aniline pentamer (AP) with the unique properties of being both electroactive and biodegradable is synthesized by coupling an electroactive carboxyl-capped AP with two biodegradable bi-hydroxyl-capped PLAs via a condensation reaction. Three different molecule weight PAP copolymers are prepared. The PAP copolymers exhibit excellent electroactivity similar to the AP and polyaniline, which may stimulate cell proliferation and differentiation. The electrical conductivity of the PAP2 copolymer film (∼5×10
−6
S/cm) is in the semiconducting region. Transmission electron microscopic results suggest that there is microphase separation of the two block segments in the copolymer, which might contribute to the observed conductivity. The biodegradation and biocompatibility experiments
in vitro prove the copolymer is biodegradable and biocompatible. Moreover, these new block copolymer shows good solubility in common organic solvents, leading to the system with excellent processibility. These biodegradable PAP copolymers with electroactive function thus possess the properties that would be potentially used as scaffold materials for neuronal or cardiovascular tissue engineering.
Metrics
Details
- Title
- Synthesis and characterization of electroactive and biodegradable ABA block copolymer of polylactide and aniline pentamer
- Creators
- Lihong Huang - State Key Laboratory of Polymer Physics and ChemistryJun Hu - State Key Laboratory of Polymer Physics and ChemistryLe Lang - State Key Laboratory of Polymer Physics and ChemistryXin Wang - State Key Laboratory of Polymer Physics and ChemistryPeibiao Zhang - State Key Laboratory of Polymer Physics and ChemistryXiabin Jing - State Key Laboratory of Polymer Physics and ChemistryXianhong Wang - State Key Laboratory of Polymer Physics and ChemistryXuesi Chen - State Key Laboratory of Polymer Physics and ChemistryPeter I. Lelkes - Drexel UniversityAlan G. MacDiarmid - University of PennsylvaniaYen Wei - Drexel UniversityXiaohua Hu - Information Science (Informatics)
- Publication Details
- Biomaterials, v 28(10), pp 1741-1751
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Information Science
- Web of Science ID
- WOS:000244436000001
- Scopus ID
- 2-s2.0-33846294433
- Other Identifier
- 991019167331104721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Engineering, Biomedical
- Materials Science, Biomaterials