Journal article
Synthesis of macromolecular mimics of small leucine-rich proteoglycans with a poly(ethylene glycol) core and chondroitin sulphate bristles
Carbohydrate polymers, v 166, pp 338-347
15 Jun 2017
PMID: 28385241
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Small leucine-rich proteoglycans (SLRPs) are a class of molecules prevalent in almost all tissues types and are thought to be responsible for collagen organization and macro-scale biological properties. However, when they are dysfunctional or degraded, severe pathological phenotypes are observed. Here we investigate macromolecular mimics to SLRPs using poly(ethylene glycol) (PEG) as a core (replacing the protein core of natural SLRPs) and chondroitin sulphate (CS) bristle(s) in an end-on attachment (via epoxide amine reactions), mimicking the physical structure of the natural SLRPs. Poly(ethylene glycol)-diglycidyl ether (PEG-DEG) and ethylene glycol-diglycidyl ether (EG-DGE) monomers were used to incorporate CS bristles into a macromolecule that closely mimics the SLRP biglycan structure in a grafting-to strategy. The kinetics of these reactions was studied along with the specific viscosity and cytocompatibility of resulting CS macromolecules. Structures were found to incorporate two CS chains (similar to biglycan) on average and exhibited cytocompatibility equivalent to or better than CS-only controls. (C) 2017 Elsevier Ltd. All rights reserved.
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Details
- Title
- Synthesis of macromolecular mimics of small leucine-rich proteoglycans with a poly(ethylene glycol) core and chondroitin sulphate bristles
- Creators
- Sumona Sarkar - Drexel UniversityCarli Moorehead - Drexel UniversityKatsiaryna Prudnikova - Drexel UniversityCaroline L. Schauer - Drexel UniversityLynn S. Penn - Drexel UniversityMichele Marcolongo - Drexel University
- Publication Details
- Carbohydrate polymers, v 166, pp 338-347
- Publisher
- Elsevier
- Number of pages
- 10
- Grant note
- Coulter Foundation
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Materials Science and Engineering; Chemistry
- Web of Science ID
- WOS:000400213300037
- Scopus ID
- 2-s2.0-85015720531
- Other Identifier
- 991019168141804721
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InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Chemistry, Applied
- Chemistry, Organic
- Polymer Science