Journal article
Systematic errors in the measurement of peak area and peak height for overlapping peaks
Journal of Chromatography A, v 384(C), pp 301-313
Jan 1987
Abstract
Errors in in the algorithms commonly employed by integrators and data systems for the measurement of peak areas and peak heihts of overlapped peaks are re-evaluated for cases where on or both peaks is stailed. The errors due only to peak tailing (area ratio = 1) can be greater than 50% for peak area measurement by the perpendicular-drop algorithm; erros in peak height can be greater thatn 40%. Errors due to a combination of peak tailing and differences in peak size can exceed 200% for peak area and 80% for peak height. An empirical area equation, when used in conjunction with normal integration procedures, permits the accurate ( < ±4%) quantitation of overlapping peaks, provided that the valley between the peaks is less than 45%.
Metrics
Details
- Title
- Systematic errors in the measurement of peak area and peak height for overlapping peaks
- Creators
- Joe P. Folley - Louisiana State UniversityJoe Preston Foley - Chemistry
- Publication Details
- Journal of Chromatography A, v 384(C), pp 301-313
- Publisher
- Elsevier
- Number of pages
- 13
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- Chemistry
- Web of Science ID
- WOS:A1987F692200023
- Scopus ID
- 2-s2.0-0001241356
- Other Identifier
- 991021906171004721
InCites Highlights
Data related to this publication, from InCites Benchmarking & Analytics tool:
- Web of Science research areas
- Chemistry, Analytical