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Accepted (AM)Open Access (License Unspecified), Open
Journal article
T cell cytokines and the risk of blood stream infection in extremely low birth weight infants
Cytokine (Philadelphia, Pa.), v 53(2), 249
01 Feb 2011
PMID: 21145756
Featured in Collection : UN Sustainable Development Goals @ Drexel
Abstract
Cytokines mediate the host immune response to infectious micro-organisms. The objective of this study was to determine whether immune regulatory interleukins (IL-4, IL-5, IL-6, and IL-10) and inflammatory cytokines (Interferon-γ [INF-γ], tumor necrosis factor-β [TNF-β], IL-2, and IL-17) are associated with an increased risk of developing blood stream bacterial/fungal infection (BSI) in extremely low birth weight (ELBW) infants. ELBW infants from 17 NICHD Neonatal Research Network centers without early onset sepsis were studied. Cytokines were measured from blood on days 1, 3, 7, 14, and 21 after birth. 996 ELBW infants contributed a minimum of 4080 unique measurements for each cytokine during the five sampling periods. Infants with BSI had lower levels of the inflammatory cytokines IL-17 (
p
=
0.01), and higher levels of the regulatory cytokines, IL-6 (
p
=
0.01) and IL-10 (
p
<
0.001). Higher levels of regulatory cytokines relative to pro-inflammatory cytokines were associated with increased risk of BSI even after adjusting for confounding variables. In ELBW infants, the ratio of immune regulatory cytokines to inflammatory cytokines was associated with development of BSI. Altered maturation of regulatory and inflammatory cytokines may increase the risk of serious infection in this population.
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Details
- Title
- T cell cytokines and the risk of blood stream infection in extremely low birth weight infants
- Creators
- Robert L. Schelonka - University of Alabama at BirminghamAkhil Maheshwari - University of Alabama at BirminghamWaldemar A. Carlo - University of Alabama at BirminghamSarah Taylor - RTI InternationalNellie I. Hansen - RTI InternationalDiana E. Schendel - Centers for Disease Control and PreventionPoul Thorsen - Lillebaelt HospitalKristin Skogstrand - Statens Serum InstitutDavid M. Hougaard - Statens Serum InstitutRosemary D. Higgins - National Institute of Child Health and Human Developmentfor the NICHD Neonatal Research Network
- Publication Details
- Cytokine (Philadelphia, Pa.), v 53(2), 249
- Publisher
- Elsevier
- Resource Type
- Journal article
- Language
- English
- Academic Unit
- A.J. Drexel Autism Institute
- Web of Science ID
- WOS:000287272700020
- Scopus ID
- 2-s2.0-78651065638
- Other Identifier
- 991021229900704721
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- Collaboration types
- Domestic collaboration
- International collaboration
- Web of Science research areas
- Biochemistry & Molecular Biology
- Cell Biology
- Immunology